Dynamic modeling of experience sampling methodology data reveals large heterogeneity in [BPS] factors associated w/persistent fatigue... 2023 Nijhof

[Andy]

Full title: Dynamic modeling of experience sampling methodology data reveals large heterogeneity in biopsychosocial factors associated with persistent fatigue in young people living with a chronic condition

Highlights
• Individual dynamic single-case networks complement group-level research.
• Biopsychosocial associations with fatigue were heterogeneous between participants.
• The associations with fatigue differed widely in direction and strength.
• The heterogeneity supports the need for personalized treatment of fatigue.
Abstract

Objective
To evaluate associations between self-reported biopsychosocial factors and persistent fatigue with dynamic single-case networks.

Methods
31 persistently fatigued adolescents and young adults with various chronic conditions (aged 12 to 29 years) completed 28 days of Experience Sampling Methodology (ESM) with five prompts per day. ESM surveys consisted of eight generic and up to seven personalized biopsychosocial factors. Residual Dynamic Structural Equation Modeling (RDSEM) was used to analyze the data and derive dynamic single-case networks, controlling for circadian cycle effects, weekend effects, and low-frequency trends. Networks included contemporaneous and cross-lagged associations between biopsychosocial factors and fatigue. Network associations were selected for evaluation if both significant (α < 0.025) and relevant (β ≥ 0.20).

Results
Participants chose 42 different biopsychosocial factors as personalized ESM items. In total, 154 fatigue associations with biopsychosocial factors were found. Most associations were contemporaneous (67.5%). Between chronic condition groups, no significant differences were observed in the associations. There were large inter-individual differences in which biopsychosocial factors were associated with fatigue. Contemporaneous and cross-lagged associations with fatigue varied widely in direction and strength.

Conclusions
The heterogeneity found in biopsychosocial factors associated with fatigue underlines that persistent fatigue stems from a complex interplay between biopsychosocial factors. The present findings support the need for personalized treatment of persistent fatigue. Discussing the dynamic networks with the participant can be a promising step towards tailored treatment.

Open access, https://www.sciencedirect.com/science/article/pii/S0022399923000508

 

[Andy]

"In the present study, we derive dynamic single-case networks from the ESM data of 31 persistently fatigued young people living with a chronic condition (i.e., Q-Fever Fatigue Syndrome (QFS), Juvenile Idiopathic Arthritis (JIA), CFS/ME and long-COVID). Conceptualizing fatigue as a generic symptom, we expect no structural differences between chronic condition groups in dynamic associations. This, we will explore as supplementary material. The main focus of the present study will be to explore persistent fatigue and associated biopsychosocial factors at the individual level. Based on the biopsychosocial model of fatigue, we expect to find a unique interplay of factors for each individual. In other words, we expect to observe large heterogeneity at the individual level regarding which biopsychosocial factors are associated with persistent fatigue and how."

 

[MeSci]

Have they got degrees in idiocy?

"The heterogeneity found in biopsychosocial factors" means that they are barking up the wrong tree!

 

[rvallee]

That's one way of presenting having no relevant data to support a long-asserted conclusion. A terribly misleading one, but still it's one way. Of course those factors are heterogenous, they're not important. You would likely find the same about musical or food preferences.

Never has a solution been so desperate to find a problem for it. The important question is how this mindless obsession just keeps going and going despite having never found anything useful. Pure fanaticism at this point.

 

[SNT Gatchaman]

Most childhood diseases can be better controlled today thanks to continuous development in pediatric medicine. Nevertheless ... [fatigue = nebulous generic symptom associated with being chronically ill but clearly nothing to do with the chronic biological illness we do not fully understand because we can't cure it.]

Follows on with —

The majority of the observed associations with fatigue was contemporaneous (67.5%). Moreover, in the personalized factors, almost no cross-lagged associations with ‘biopsychosocial factor first’ were observed. Either the factors observed were indeed all contemporaneous or following after fatigue

Still leads to —

In conclusion, the large heterogeneity found across participants in dynamic single-case networks results makes it likely that persistent fatigue is the result of a complex interplay between biopsychosocial factors while growing up with a chronic condition.

The heterogeneity found in biopsychosocial factors associated with fatigue underlines that persistent fatigue stems from a complex interplay between biopsychosocial factors has no relationship to biopsychosocial factors.

 

[Sean]

Conclusions
The heterogeneity found in biopsychosocial factors associated with fatigue underlines that persistent fatigue stems from a complex interplay between biopsychosocial factors. ​

It does no such thing.

The present findings support the need for personalized treatment of persistent fatigue. ​

It does no such thing.

Discussing the dynamic networks with the participant can be a promising step towards tailored treatment.​

Vague hand-waving nonsense with no empirical support or internal consistency whatsoever.

Peer-review on this stuff is methodologically and ethically bankrupt.

Never has a solution been so desperate to find a problem for it.

A non-solution.

 

[rvallee]

Literally all they have at this point is "the mind works in mysterious ways". It's not borderline religious, it is entirely a faith-based system. There are many less mystical religions out there. It wouldn't be half as ridiculous, and harmful, if they didn't turn around pretending they know all about it anyway, as long as it's through BPS narratives and stories.

One of the worst ideologies ever unleashed on the world. So much harm. So much stagnation. Millions of lives destroyed for absolutely nothing but mediocre folklore.

 

[Grigor]

A Dutch article by Q-Support that supports people with Long Q-Fever that also refers to this publication:

https://www.q-support.nu/onderzoek-...HgPUD9jzSv-pdTb4omQ-eut_jO4xlsbIj7YjZ8UcEcmjk

The biomedical research looks quite interesting, but the BPS stuff looks awful as always.