Double-seropositive Myasthenia Gravis Following COVID-19: A case report, 2025, Hiraoka et al

Double-seropositive Myasthenia Gravis Following COVID-19: A case report

Yuki Hiraoka, Yasushi Hosoi, Takuya Tsubata, Miharu Yanagida, Yusuke Otake, Michiko Ito

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Abstract
Myasthenia gravis (MG) is an autoimmune disease characterized by muscle weakness caused by antibodies targeting acetylcholine receptors (AChRs) or muscle-specific kinases (MuSK). Double-seropositive MG (DSP-MG) caused by both antibodies is rare.

We herein report a 78-year-old woman who developed DSP-MG after COVID-19 infection. She presented with neck muscle fatigue and upper-limb weakness. Elevated levels of anti-AChR and anti-MuSK antibodies were detected. The patient responded well to the immunosuppressive therapy.

This case highlights the potential for various autoimmune neurological conditions post-viral infection and the significance of prompt recognition and treatment.

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