Disturbance of mitochondrial dynamics and mitophagy in sepsis-induced acute kidney injury, 2019, Liu et al

Andy · Sep 4, 2019

In mice.

Abstract
Aims
The renal tubule cells require a large number of mitochondria to supply ATP due to their high-energy demand during reabsorption and secretion against chemical gradients and result in mitochondria susceptible to disorder and injury during stress conditions. Injured mitochondria are eventually degraded by mitophagy, and disturbances in mitophagy are associated with the pathogenesis of acute kidney injury (AKI) such as diabetic nephropathy and glomerulosclerosis. However, whether a disturbance in mitophagy has occurred and the role it plays in (SAKI) is still unclear. Therefore, the aim of this study was to investigate the key features of mitophagy and mitochondrial dynamics in sepsis-induced acute kidney injury (SAKI).

Main methods
In this study, a murine septic AKI model induced by cecal ligation and puncture (CLP) was built; mitophagy and mitochondrial dynamics were measured in mice kidney in different time point.

Key findings
The results showed that mitochondrial dynamics were characterized by fission/fusion aberrant, however more inclined to fission, and mitochondrial associated apoptosis was elevated over-time during SAKI. Furthermore, mitophagy was impaired in the later phase of SAKI, although elevated in early stage of SAKI. The results indicate that the underlying mechanisms of impaired mitophagy may associate with the cleavage of Parkin via caspases activated by NLRP3, at least partly.

Significance
It is conceivable that this selective autophagic process and quality control machinery was impaired, leading to the accumulation of damaged mitochondria, oxidative stress, and cell death. Therefore, a targeted approach, by enhancing mitophagy during SAKI, may be a promising therapeutic strategy.
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Paywall, https://www.sciencedirect.com/science/article/abs/pii/S0024320519307556
Not currently available on Sci hub.

mariovitali · Sep 10, 2019

This might be highly relevant to ME patients. I am finding several pieces of information pointing to chronic kidney disease or impaired renal function.

An example :

https://sci-hub.tw/10.1080/21641846.2016.1207400

Also the paper is now available on SciHub : https://sci-hub.tw/10.1016/j.lfs.2019.116828

Thank you @Andy

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Disturbance of mitochondrial dynamics and mitophagy in sepsis-induced acute kidney injury, 2019, Liu et al

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Disturbance of mitochondrial dynamics and mitophagy in sepsis-induced acute kidney injury, 2019, Liu et al

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