Delayed-type hypersensitivity to metals in connective tissue diseases and fibromyalgia, 2017, Bjorklund et al

[Sly Saint]

Abstract
Rheumatic diseases include a group of autoimmune disorders with environmental and genetic etiology that are characterized as a subgroup of connective tissue diseases (CTD). Rheumatoid arthritis (RA) often involves the small joints of the hands in a symmetrical fashion that can lead to loss of joint function, and RA, as well as Sjögren's syndrome (SS) and other rheumatic diseases, are often accompanied by sensitivity to metals. Numerous investigations on metal sensitivity were evaluated in this review.

A detailed metal exposure history was collected by different evaluation of studies. In all subjects, the main source of metal exposure was nickel, mercury, gold, palladium, titanium, and chromium. All of SLE (systemic lupus erythematosus), RA and SS patients appeared to have an increased frequency of metal delayed-type hypersensitivity (DTH) (Type IV allergy).

As dental restorative materials release minor amounts of their metals (including mercury, gold, and nickel), many adults are commonly exposed to these metal ions by vapor or corrosion into saliva. Metal-related DTH in these patients will induce an inflammatory response. Such inflammations are important factors in CTD progress.

It is hypothesized that metal-specific T cell reactivity can act as an etiological agent in the propagation and chronification of rheumatic inflammation. The key responses of metal delayed-type hypersensitivity in autoimmunity are precipitating as an appealing challenge for further investigations.

https://www.sciencedirect.com/science/article/abs/pii/S0013935117317280?via=ihub

 

[Jonathan Edwards]

Why are so many of these junk papers published by Elsevier I wonder?

This reads exactly like one of those computer fakes.

Dial in rheumatoid arthritis and metal sensitivity and ask for a computer-generated paper.

The introduction is exactly what you should get - full of evidence, as required by the Turing test, that the material was not actually written by an intelligent being.

The data are exactly as expected - in that they are exactly as the authors expected.

The conclusions follow as byte follows byte.

An almost perfect case of pseudoscience.