Andy
Senior Member (Voting rights)
Abstract
Aerobic exercise prescription is often set at specific heart rate (HR) values. Previous studies demonstrated that during exercise carried out at a HR slightly above that corresponding to the gas exchange threshold (GET), work rate (WR) has to decrease in order to maintain HR constant. We hypothesized a greater WR decrease at a fixed HR following simulated microgravity/inactivity (bed rest, BR).
Ten male volunteers (23±5 yr) were tested before (PRE) and after (POST) a 10-day horizontal BR, and performed on a cycle ergometer: a) incremental exercise; b) 15-min HRCLAMPED exercise, in which WR was continuously adjusted to maintain a constant HR, corresponding to that at 120% of GET determined in PRE; c) two moderate-intensity constant WR (MOD) exercises. Breath-by-breath VO2, HR and other variables were determined.
After BR, VO2peak and GET significantly decreased, by about 10%. During HRCLAMPED (145±11 b∙min-1), the decrease in WR needed to maintain a constant HR was greater in POST vs. PRE (-39±10 vs. -29±14%, p<0.01). In 6 subjects the decreased WR switched from the heavy- to the moderate-intensity domain. The decrease in WR during HRCLAMPED, in PRE vs. POST, was significantly correlated with the VO2peak decrease (R2=0.52; p=0.02). A greater amplitude of the slow component of the HR kinetics was observed during MOD following BR. Exercise at a fixed HR is not associated with a specific WR or WR domain; the problem, affecting exercise evaluation and prescription, is greater following BR. The WR decrease during HRCLAMPED is a biomarker of exercise intolerance following BR.
Paywall, https://journals.physiology.org/doi/abs/10.1152/japplphysiol.00052.2022
Aerobic exercise prescription is often set at specific heart rate (HR) values. Previous studies demonstrated that during exercise carried out at a HR slightly above that corresponding to the gas exchange threshold (GET), work rate (WR) has to decrease in order to maintain HR constant. We hypothesized a greater WR decrease at a fixed HR following simulated microgravity/inactivity (bed rest, BR).
Ten male volunteers (23±5 yr) were tested before (PRE) and after (POST) a 10-day horizontal BR, and performed on a cycle ergometer: a) incremental exercise; b) 15-min HRCLAMPED exercise, in which WR was continuously adjusted to maintain a constant HR, corresponding to that at 120% of GET determined in PRE; c) two moderate-intensity constant WR (MOD) exercises. Breath-by-breath VO2, HR and other variables were determined.
After BR, VO2peak and GET significantly decreased, by about 10%. During HRCLAMPED (145±11 b∙min-1), the decrease in WR needed to maintain a constant HR was greater in POST vs. PRE (-39±10 vs. -29±14%, p<0.01). In 6 subjects the decreased WR switched from the heavy- to the moderate-intensity domain. The decrease in WR during HRCLAMPED, in PRE vs. POST, was significantly correlated with the VO2peak decrease (R2=0.52; p=0.02). A greater amplitude of the slow component of the HR kinetics was observed during MOD following BR. Exercise at a fixed HR is not associated with a specific WR or WR domain; the problem, affecting exercise evaluation and prescription, is greater following BR. The WR decrease during HRCLAMPED is a biomarker of exercise intolerance following BR.
Paywall, https://journals.physiology.org/doi/abs/10.1152/japplphysiol.00052.2022
