CRISPR has been used to treat a rare genetic disease i.e. by injecting lipid nanoparticles containing the RNA into the bloodstream. OK we don't know the cause of ME/CFS and/or whether switching off genes would help but the technology interested me.
https://www.sciencemag.org/news/2021/06/crispr-injected-blood-treats-genetic-disease-first-time
https://www.sciencemag.org/news/2021/06/crispr-injected-blood-treats-genetic-disease-first-time