COVID-19 Recovery and Cardiovascular Health: The Interplay Between Fetuin-A and Blood Pressure, 2024, Ramadan et al.

COVID-19 Recovery and Cardiovascular Health: The Interplay Between Fetuin-A and Blood Pressure
Montather F. Ramadan; Iqbal J. Al-Assadi ; Foued B. Hadj Slama; Montather F. Ramadan; Iqbal J. Al-Assadi ; Foued B. Hadj Slama

INTRODUCTION
COVID-19 has been shown to impair cardiovascular function, and further studies have proven that this effect can be long-term on several cardiovascular biomarkers. Fetuin-A, a multifunctional protein involved in calcification and inflammation, has emerged as an important biomarker in this process. This study investigates the relationship between recovery from COVID-19, cardiovascular health, and concentrations of fetuin-A in patients with high blood pressure.

METHODS
Seventy-nine men and 36 women were admitted to the Nasiriyah Heart Center in Iraq between March and August 2023, with ages ranging from 5 to 93 years. Clinical data were collected on admission along with blood samples, and serum levels of fetuin-A were measured using an enzyme-linked immunosorbent assay (ELISA). The results were analyzed using Python libraries Pandas and SciPy to perform independent sample t-tests to determine mean levels of fetuin-A in various patient subgroups. A p-value of less than 0.05 was considered statistically significant.

RESULTS
The study showed that patients who had survived COVID-19 had significantly higher levels of fetuin-A compared to healthy controls, with a mean concentration of 103.64 mg/L versus 19.199 mg/L (p < 0.001). Additionally, it was found that patients with high blood pressure had increased levels of fetuin-A compared to those without high blood pressure, with a mean concentration of 109.01 mg/L versus 95.88 mg/L (p = 0.025). These results suggest that COVID-19 may alter the usual relationship between blood pressure and cardiovascular biomarkers.

CONCLUSIONS
This study emphasizes the complex interaction between recovery from COVID-19 and cardiovascular health, primarily through the levels of fetuin-A. The increase in fetuin-A among hypertensive patients suggests that COVID-19 may enhance cardiovascular risk, highlighting the need for stricter monitoring and tailored treatment strategies. Further studies are needed to elucidate the underlying mechanisms, which will help develop effective clinical guidelines for managing cardiovascular health in COVID-19 survivors.

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The paper's a little repetitive but fetuin has been noted to be elevated in LC eg Vascular Inflammation in Neuropsychiatric Long Covid (2024, Preprints with the Lancet) —