Mij
Senior Member (Voting Rights)
A bacterial driver of arthritis
Autoantibodies can be detected in individuals at risk for developing rheumatoid arthritis (RA) before development of clinical disease. The source of these autoantibodies, however, remains unclear. Here, Chriswell et al. identified that IgG and IgA autoantibodies from individuals who are at risk for RA cross-react against gut bacteria in the Lachnospiraceae and Ruminococcaceae families. Further analysis identified a bacterial strain from the Subdoligranulum genus that was associated with autoantibody development. Mice colonized with this Subdoligranulum isolate developed arthritis with pathology similar to human RA.
These findings suggest that this Subdoligranulum strain may be a major contributor to RA autoantibody development.
https://theconversation.com/newly-d...-a-culprit-behind-rheumatoid-arthritis-193267
@Jonathan Edwards
Autoantibodies can be detected in individuals at risk for developing rheumatoid arthritis (RA) before development of clinical disease. The source of these autoantibodies, however, remains unclear. Here, Chriswell et al. identified that IgG and IgA autoantibodies from individuals who are at risk for RA cross-react against gut bacteria in the Lachnospiraceae and Ruminococcaceae families. Further analysis identified a bacterial strain from the Subdoligranulum genus that was associated with autoantibody development. Mice colonized with this Subdoligranulum isolate developed arthritis with pathology similar to human RA.
These findings suggest that this Subdoligranulum strain may be a major contributor to RA autoantibody development.
https://theconversation.com/newly-d...-a-culprit-behind-rheumatoid-arthritis-193267
@Jonathan Edwards