Chronic Lyme disease, post-treatment Lyme disease syndrome (PTLDS)

Just to say here, that in a meeting held by the TAL Research group (Michal Tal), I gave specific targets of interest related to Lyme disease. Interestingly, Lyme disease disrupts phospholipids and also uses Heparan Sulfate (a Glycosaminoglycan) to attach to the host.

Both of these may be key factors for the ongoing symptoms in some patients.
 
Updating Lyme World is akin to updating US politics: It's massive and unwieldy and goes in countless directions.

The Science has inched along, but not the diagnostics. We know antibiotics often fail to eradicate Borrelia, but this is hard to prove with today's diagnostic menu. We know some patients improve on long term abx. We know some do not and in fact can be made worse on them

Lyme World is arguably divided into three territories: Infectious disease clinicians/researchers, ILADS clinicians/researchers, and the patients.

But the short of it is that unless Lyme is caught very early, the patient community is in many ways no better off in 2026 than it was in 1976.

II need to stop for now. I will continue this later.
 
Where do things stand right now in Lyme World?


Things are tribal. Everyone sticks to their own group, their own beliefs. Newbies come and have to sift through scatterings of propaganda and science. Then they have to make a judgement that is sure to be based on incomplete data.

Before I got sick, I was a partner in a research firm. I researched stuff 24/7.

I still haven't managed to entirely grasp who believes in what is true, who believes in what is glaringly false, and who is just straight up lying.

I do know that in the US close to 500,000 will get Lyme this year, and maybe as many as 20% of those will not get well.

The CDC and the NHS and leading academics and tick-borne disease credentialed clinicians all contribute, each in their own way, to the persistent crazy stall of progress.

The appalling complexities at play do not help.
 
Worth following Mayo. Tulane and Columbia . Brian Fallon worth a read. German orthodoxy is sceptical about e.g Eli and Ispot but have no problem with the terms chronische Neuroborreliose or Borreliose mit chronischem Verlauf (course). Terms used in Aertzteblatt. I asked AI if AB was about the level of National Enquirer etc. but it said it is a lot better.
 
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