Over-the-counter antihistamine loratadine busts bacterial biofilms and helps oxacillin to kill antibiotic-resistant Staphylococcus aureus in the lab
The common antihistamine loratadine—the active ingredient in over-the-counter medications such as Claritin, Alerclear, and Alavert—makes some species of antibiotic-resistant bacteria susceptible to antibiotics in lab experiments (ACS Infect Dis. 2019, DOI: 10.1021/acsinfecdis.9b00096). Loratadine alone also breaks up bacterial biofilms, tight-knit microbial communities that form on implants and catheters and make resistance worse. The results offer a new route to developing drugs for these hard-to-treat infections, the researchers say.
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