Background
Muscle mitochondrial dysfunction associated with HIV and antiretroviral therapy (ART) may improve with exercise.
Methods
Muscle specimens obtained before and after 24 weeks of exercise in older PWH (n=18; ART >2 years) and uninfected controls (n=21) were analyzed for citrate synthase (CS) activity and complexes (C) I-V, manganese superoxide dismutase (MnSOD), peroxisome proliferator-activated receptor-γ coactivator-1 (PGC1α), and voltage-dependent anion channel 1 (VDAC1) content.
Results
Only controls had increased CS, MnSOD, PGC1 and CIV (P≤0.01; P< 0.01 vs PWH) after training.
Conclusions
The blunted mitochondrial adaptations to training in PWH suggests the need for different types of exercise-induced stimulation.
