Review Beyond neurotransmission: acetylcholine in immunity and inflammation 2019 Cox et al

Abstract

Acetylcholine (ACh) is best known as a neurotransmitter and was the first such molecule identified. ACh signalling in the neuronal cholinergic system has long been known to regulate numerous biological processes (reviewed by Beckmann and Lips).

In actuality, ACh is a ubiquitous signalling molecule that is produced by numerous non-neuronal cell types and even by some single-celled organisms. Within multicellular organisms, a non-neuronal cholinergic system that includes the immune system functions in parallel with the neuronal cholinergic system. Several immune cell types both respond to ACh signals and can directly produce ACh.

Recent work from our laboratory has demonstrated that the capacity to produce ACh is an intrinsic property of T cells responding to viral infection, and that this ability to produce ACh is dependent upon IL-21 signalling to the T cells. Furthermore, during infection this immune-derived ACh is necessary for the T cells to migrate into infected tissues.

In this review, we will discuss the various sources of ACh that are relevant during immune responses and describe how ACh acts on immune cells to influence their functions. We will also address the clinical implications of this fascinating aspect of immunity, focusing on ACh’s role in the migration of T cells during infection and cancer.

Open access, https://onlinelibrary.wiley.com/doi/full/10.1111/joim.13006

 

A very timely reminder, @Andy.

How could I have forgotten? In myasthenia antibodies to ACh receptors are linked to thymic hyperplasia and thymoma. The receptors on lymphocytes and thymic myoid cells are muscarinic which is puzzling since the antibodies target nicotinic receptors but the link remains.