On how anti-aging therapies could piggyback on autoimmune treatment strategies in the same way the latter piggybacked on advances in cancer therapies https://www.writingruxandrabio.com/p/autoimmune-therapies-an-inspiration
Twitter feed if that’s easier to read. https://twitter.com/user/status/1914393455754695144 Highly speculative post: Autoimmune diseases have benefitted from a repurposing of modalities from blood malignancies. Imo, once we find the immune cell subpopulations driving age-related diseases, we'll see repurposing from autoimmune -> aging
Yer, well, that occurred to Jo C and I in 2000 - 25 years ago - and we went around saying we should all have a shot of ritux to ensure eternal youth. (I guess Ruxandra might have been in nappies then.) Things ain't quite that simple though!! It may be a bit like jogging - it probably prolongs your life for exactly the length of time you are in misery running up and down - or sitting having your ritux infusions. Why don't people read the literature?
Aren't most age-related disease due to telomeres reaching their "no more replacement" limit? Well, there's also accumulated debris and damage that doesn't have a mechanism for repair or doesn't get recognized as needing replacement of the whole cell.
Too disappointing? It's much more exciting to read about a new pill that is going to make you slim, trim and healthy forever.
That’s one of the things associated with aging. My former rotation lab also did some interesting work associating the length of a gene with abnormalities in aging—the idea being that all transcriptional machinery seems to become less efficient with age, so longer genes have more opportunities to go wrong and never become a functional protein. This could have all sorts of other downstream effects. There’s also epigenetic changes associated with aging, changes in immune cells, some changes in mTOR signaling (that have yet to be fruitful) etc. etc. etc. Long story short, there’s no short story
Probably not, that is the problem for the person who reaches 112, having not got cancer or blocked arteries or Alzheimer's neurofibrillary tangles.
