Association of Baseline Cerebrovascular Reactivity and Development of Enlarged Perivascular Spaces in the Basal Ganglia, 2023, Libecap et al.

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Preprint
Association of Baseline Cerebrovascular Reactivity and Development of Enlarged Perivascular Spaces in the Basal Ganglia
Timothy J Libecap; Christopher E Bauer; Valentinos Zachariou; Colleen A Pappas; Flavius D Raslau; Peiying Liu; Hanzhang Lu; Brian T Gold

Background:
Increasing evidence suggests that enlarged perivascular spaces (ePVS) are associated with cognitive dysfunction in aging. However, the etiology of ePVS remains unknown. Here we tested the possibility that baseline cerebrovascular dysfunction, as measured by an MRI measure of cerebrovascular reactivity (CVR), contributes to the later development of ePVS.

Methods:
A total of 79 cognitively normal, older adults (46 women, age range 60-84) were recruited to undergo MRI scanning at baseline and 50 participants returned for a follow-up scan approximately 2.5 years later. ePVS were counted in the basal ganglia, centrum semiovale, midbrain, and hippocampus. CVR, an index of the vasodilatory capacity of cerebral small vessels, was assessed using carbon-dioxide inhalation while acquiring blood oxygen-level dependent (BOLD) MR images.

Results:
Low baseline CVR values in the basal ganglia were associated with increased follow-up ePVS counts in the basal ganglia after controlling for age, sex, and baseline ePVS values (coefficient estimate (SE) = -15.87 (3.92), p < 0.001, 95% confidence interval [CI] -23.68 to -8.05). This effect remained significant after accounting for self-reported risk factors of cerebral small vessel disease (cSVD) (coefficient estimate (SE) = -15.03 (4.00), p < 0.001, CI -23.02 to -7.05) and neuroimaging markers of cSVD (coefficient estimate (SE) = -13.99 (4.02), p < 0.001, CI -22.03 to -5.95).

Conclusions:
Our results demonstrate that low baseline CVR is a risk factor for later development of ePVS. MRI-based CVR may represent a promising biomarker of cSVD.

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Published as —

Association of Baseline Cerebrovascular Reactivity and Longitudinal Development of Enlarged Perivascular Spaces in the Basal Ganglia (2023)
T.J. Libecap; Christopher E. Bauer; Valentinos Zachariou; Colleen A. Pappas; Flavius D. Raslau; Peiying Liu; Hanzhang Lu; Brian T. Gold

BACKGROUND
Increasing evidence suggests that enlarged perivascular spaces (ePVS) are associated with cognitive dysfunction in aging. However, the pathogenesis of ePVS remains unknown. Here, we tested the possibility that baseline cerebrovascular dysfunction, as measured by a magnetic resonance imaging measure of cerebrovascular reactivity, contributes to the later development of ePVS.

METHODS
Fifty cognitively unimpaired, older adults (31 women; age range, 60–84 years) underwent magnetic resonance imaging scanning at baseline and follow-up separated by ≈2.5 years. ePVS were counted in the basal ganglia, centrum semiovale, midbrain, and hippocampus. Cerebrovascular reactivity, an index of the vasodilatory capacity of cerebral small vessels, was assessed using carbon dioxide inhalation while acquiring blood oxygen level-dependent magnetic resonance images.

RESULTS
Low baseline cerebrovascular reactivity values in the basal ganglia were associated with increased follow-up ePVS counts in the basal ganglia after controlling for age, sex, and baseline ePVS values (estimate [SE]=−3.18 [0.96]; P=0.002; [95% CI, −5.11 to −1.24]). This effect remained significant after accounting for self-reported risk factors of cerebral small vessel disease (estimate [SE]=−3.10 [1.00]; P=0.003; [CI, −5.11 to −1.09]) and neuroimaging markers of cerebral small vessel disease (estimate [SE]=−2.72 [0.99]; P=0.009; [CI, −4.71 to −0.73]).

CONCLUSIONS
Our results demonstrate that low baseline cerebrovascular reactivity is a risk factor for later development of ePVS.

Link | PDF (Stroke)