One article I read from ECTRIMS (behind paywall) was that one group of researchers presented findings that people who go on to have an MS diagnosis have increased sick leave starting ~ten years before diagnosis. Indicating a long prodromal phase.
Found a non-paywalled article that also include a link to a pdf of the study presentation:
ECTRIMS 2023: Sick days in years before diagnosis suggest MS prodrome This was based on data from Sweden. In Norway we recently got data that showed people who go on to get an ME diagnosis lose income starting ~three years pre diagnosis.
