Acupuncture of the Beishu acupoint participates in regulatory effects of ginsenoside Rg1 on T cell subsets of rats with [CFS], 2020, Zhang et al

[Andy]

For what it's worth. More chronically fatigued rats.

Background: There are close relationships between the spleen and limb muscles and thoughts. The study aims to test the effects of ginsenoside Rg1 in combination with acupuncture of the Beishu acupoint on T cell subsets of rats with chronic fatigue syndrome (CFS).

Methods: The model was set up by combining forced cold-water swimming with chronic restraint. The rats were randomly divided into blank control, model, ginsenoside, acupuncture, and ginsenoside plus acupuncture groups (n=10). For the acupuncture group, the Beishu acupoint was acupunctured on the 2nd day after modeling. For the ginsenoside group, the ginsenoside Rg1 solution was injected into the tail vein on the 2nd day after modeling. For the combination group, both processes were conducted. These groups were compared regarding exhausted swimming time, number of struggles, resting time, serum levels of IgA, IgG, IgM, IFN-α, IFN-β, and IFN-γ, lymphocyte transformation rate, T cell subsets, and skeletal muscle activities of malondialdehyde (MDA), total antioxidative capacity (T-AOC) and acetylcholinesterase (Ache).

Results: The exhausted swimming time, number of struggles, and resting time of combination group surpassed those in the ginsenoside and acupuncture groups significantly (P<0.05). The serum levels of IgA, IgG, IgM, IFN-β, IFN-γ, T-AOC, and Ache, together with CD3+ and CD8+ T cell percentages of combination groups, were significantly higher than those of ginsenoside and acupuncture groups. However, the IFN-α level, MDA activity, and CD4+ T cell percentage were significantly lower (P<0.05). Compared with the model group, the CD4+/CD8+ T cell ratios of acupuncture, ginsenoside, and combination groups decreased significantly (P<0.05). Compared with the combination group, the ratio of the ginsenoside group increased significantly (P<0.05).

Conclusions: Both acupuncture of the Beishu acupoint and intravenous injection of ginsenoside Rg1 have anti-fatigue effects, and their combination works synergistically. This study supplies an experimental basis for joint therapy using acupuncture and drugs to combat fatigue synergistically.

Open access, http://apm.amegroups.com/article/view/52609/html

 

[Wonko]

Have these rats been fully screened to rule out other conditions, like MS, cancer, depression, a slight sniffle?

Do these rats suffer from PEM?

Have these rats been ill for at least 6 months?

Have they been subjected to years of medical decision, disbelief, cruelty and GET/CBT?

What diagnostic evaluation (Oxford, Fukuda, CCC, etc) was done to determine that CFS was a likely diagnosis, given that, in humans there are no medical tests, that are actually performed or understood by doctors, that show someone has CFS - a diagnosis is largely made from reported 'history'. How did the rats provide this 'history'?


Or have they simply been tortured into complete exhaustion until they are 'depressed' to the point of being suicidal?

(Has anyone considered that the rats may simply move more coz they are trying to get away from the sadist with the needles?)