Accelerating biomedical discoveries in brain health through transformative neuropathology of aging and neurodegeneration, 2025, Murray et al.

[Jaybee00]

Summary​

Transformative neuropathology is redefining human brain research by integrating foundational descriptive pathology with advanced methodologies. These approaches, spanning multi-omics studies and machine learning applications, will drive discovery for the identification of biomarkers, therapeutic targets, and complex disease patterns through comprehensive analyses of postmortem human brain tissue. Yet critical challenges remain, including the sustainability of brain banks, expanding donor participation, strengthening training pipelines, enabling rapid autopsies, supporting collaborative platforms, and integrating data across modalities. Innovations in digital pathology, tissue quality enhancement, harmonization of data standards, and machine learning integration offer opportunities to accelerate tissue-level “pathomics” research in brain health through cross-disciplinary collaborations. Lessons from neuroimaging, particularly in establishing common data frameworks and multi-site collaborations, offer a valuable roadmap for streamlining innovations. In this perspective, we outline actionable solutions for leveraging existing resources and strengthening collaboration -where we envision future opportunities to drive translational discoveries stemming from transformative neuropathology.

https://www.cell.com/neuron/fulltext/S0896-6273(25)00472-6

 

[Utsikt]

That entire abstract reads like something written by a business management consultant.

Transformative neuropathology

advanced methodologies

streamlining innovations

actionable solutions

leveraging existing resources

drive translational discoveries

 

[Creekside]

Yes, it sounds like "Rah, rah!" stuff that will be tossed in the proverbial trashcan soon after (and deserves it!). Yes there's progress in understanding how the brain works, but there's also a lot of mystery. I get the impression that 50 years from now there will still be plenty of new discoveries that show that "what is known" about the brain was completely wrong.

Maybe that was an experiment in AI-generated blather? Maybe they'll tally how many people respond with "Wow, that's brilliant!" That's actually a valid study: to see how vulnerable people are to that sort of manipulation.

 

[Sean]

I learned nothing from reading that, beyond that it was a waste of time to read it.