A discrete neuronal circuit induces a hibernation-like state in rodents (2020) Takahashi et al

Colin

Colin

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Hibernating mammals actively lower their body temperature to reduce energy expenditure when facing food scarcity. This ability to induce a hypometabolic state has evoked great interest owing to its potential medical benefits. Here we show that a hypothalamic neuronal circuit in rodents induces a long-lasting hypothermic and hypometabolic state similar to hibernation. In this state, although body temperature and levels of oxygen consumption are kept very low, the ability to regulate metabolism still remains functional, as in hibernation. There was no obvious damage to tissues and organs or abnormalities in behaviour after recovery from this state. Our findings could enable the development of a method to induce a hibernation-like state, which would have potential applications in non-hibernating mammalian species including humans.
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Paywall: https://www.nature.com/articles/s41586-020-2163-6

View-only access to the paper is available via the link at the end of the article in The Scientist; see below.
 
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