Dolphin
Senior Member (Voting Rights)
OURNAL OF HOSPITAL GENERAL MEDICINE
http://doi.org/10.60227/jhgmeibun.2025-0027
http://hgm-japan.com/english-2/about-the-journal/
A case of severe multiple chemical sensitivity (MCS): Proposed therapeutic strategies for MCS
Shoji Kubo1) 2)
1) Health Education Course, Department of Education, Shitennoji University
2) Department of Hepato-Biliary-Pancreatic Surgery, Osaka Metropolitan University Graduate School of Medicine
Abstract
Multiple chemical sensitivity (MCS) is hypothesized to involve chemically induced oxidative stress, systemic inflammation including hypercytokinemia, and resultant cellular dysfunction.
Here, a case of severe MCS that clinically manifested following extensive exposure to sewage leakage from a drainage system is described.
The patient exhibited a longstanding predisposition to olfactory sensitivity and gastrointestinal allergy from early childhood and had a medical history notable for spinal trauma, allergic rhinitis, chronic sinusitis, nasal polyps, electromagnetic hypersensitivity, and fungal hypersensitivity.
Therapeutic management encompassed environmental modification and avoidance or elimination of causative and exacerbating agents, alongside detoxification and metabolic support utilizing glutathione, taurine, and levocarnitine.
During episodes of acute chemical exposure, a glycyrrhizin-glycine-cysteine combination solution or placental hydrolysate solution improved symptoms.
Mirogabalin controlled symptoms related to neurohypersensitivity reactions attributable to central sensitization.
Immune modulation and anti-inflammatory interventions incorporated suplatast tosilate, montelukast, theophylline, and Saikokeishitou.
Nasal pain was ameliorated through a combination of epipharyngeal abrasive therapy with carbamazepine and/or Saikokaryukotsuboreito.
Comprehensive comorbidity management, including the treatment of allergic diseases and the removal of dental amalgam and metallic crowns, proved integral to achieving therapeutic stabilization.
The development of curative treatments and the establishment of evidence-based practice guidelines, including pharmacological interventions, remain urgent clinical needs for MCS treatment.
Keywords multiple chemical sensitivity, neurohypersensitivity, detoxification, pharmacological treatment strategy
J Hosp Gen Med 2026;8(2):61-65 http://doi.org/10.60227/jhgmeibun.2025-002