27 May 2019 seminar Lisbon - What can a bioestatician advise to acelerate the understanding of myalgic encephalomyelitis/chronic fatigue syndrome

Sly Saint

Sly Saint

Senior Member (Voting Rights)
Nuno Sepúlveda (London School of Hygiene & Tropical Medicine & CEAUL)

Abstract: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a debilitating disease with unknown cause characterized by non-specific symptoms, such as fatigue, post exertion malaise, abnormal sleep patterns and frequent viral infections.

The respective diagnostic is cumbersome due to the inexistence of a disease-specific biomarker. As a consequence, problems related to the definition of sampling population, patient’s classification, selective bias and confounding often emerge in clinical data from this disease. In addition, the respective statistical analyses involve a large number of tests exploring different hypotheses for the cause of ME/CFS.

As such, false positive results might emerge if multiple testing is properly not accounted for in the analysis. In this talk, I will discuss all these statistical problems using data from the UK ME/CFS biobank as a case study. I will also introduce the new European network on ME/CFS (EUROMENE) and how it can be used to tackle some of the above problems.
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https://ciencias.ulisboa.pt/en/node/11136
 
Looks interesting.

Though not sure about this:

"characterized by non-specific symptoms,... post exertion malaise"

Non-specific? In my experience PEM is pretty specific. The more I do the sicker I get. Broadly speaking the basic symptom profile remains unchanged, the PEM just amplifies it (or the amplification is PEM). That phenomenon is quite distinct from my perspective.
 
Sean said:
Looks interesting.

Though not sure about this:

"characterized by non-specific symptoms,... post exertion malaise"

Non-specific? In my experience PEM is pretty specific. The more I do the sicker I get. Broadly speaking the basic symptom profile remains unchanged, the PEM just amplifies it (or the amplification is PEM). That phenomenon is quite distinct from my perspective.
Click to expand...
Surely in a sense all symptoms are nonspecific. If I go to the doctor with difficulty swallowing, they don't immediately diagnose cancer of the oesophagus. It's the pattern of symptoms that is more useful.
 
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