viral persistence

Persistent SARS-CoV-2 Spike is Associated with Localized Immune Dysregulation in Long COVID Gut Biopsies [Line breaks added] Abstract SARS-CoV-2 persistence is a proposed driver of Long COVID (LC), but the in-situ relationship between residual viral antigen and immune dysregulation remains...

Persistent Gut-Immune Axis dysregulation in long-term Post-COVID Syndrome: Insights from a prospective, observational, cross-sectional case-control study Post-COVID syndrome (PCS) is a complex condition that can emerge after recovery from SARS-CoV-2 infection, even in young, healthy...

A phase 2a double-blind, placebo-controlled randomized trial of the SARS-CoV-2-specific monoclonal antibody AER002 in people with Long COVID Long COVID is a disabling chronic illness with no proven treatments. Persistence of SARS-CoV-2 has been proposed as a biological driver of the disease...

CD169+ and HLA-DR+ extracellular vesicles are highly represented in human plasma and dynamically expressed in SARS-CoV-2 infection and long COVID-associated sequelae INTRODUCTION Elevated inflammation and immune dysregulation are the main consequences of severe acute respiratory syndrome...

Abstract The Persistence of SARS-CoV-2 in tissues has been proposed as a driver of prolonged symptoms in long COVID. Pulmonary rehabilitation with exercise training is a well-established intervention for improving symptoms, functional capacity, and inflammation in chronic cardiorespiratory...

Disruption of the hypothalamic orexin system links SARS-CoV-2 infection to persistent cortical neuronal pathology Long COVID frequently presents with persistent neurological symptoms, including cognitive impairment, fatigue, and sleep disturbances; however, its underlying mechanisms remain...

Post-COVID impairment of memory T cell responses to community-acquired pathogens can be rectified by activating cellular metabolism Infection rates involving bacterial and viral pathogens have increased precipitously after the COVID-19 pandemic. While it has been speculated that higher...

Broadly neutralizing antibodies to SARS-CoV-2 in Long COVID are associated with viral persistence and clinical outcome Chenyu Liu, Daniel Sanson, Serhan Soylu, Leen Moens, Isabelle Meyts, Marc Jamoulle, Johan Van Weyenbergh [Line breaks added] Abstract Long COVID (also known as post-acute...

Abstract Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating chronic condition without a definitive aetiology, no reliable diagnostic test, and no proven effective treatment. Despite most patients reporting a post-viral onset of illness, findings to date are conflicting...

A highly divergent sample from a nearly extinct SARS-CoV-2 lineage in a patient with long-term COVID-19 BACKGROUND Although COVID-19 is primarily an acute disease, there are cases of persistent infection, primarily in immunocompromised patients. It is hypothesized that at least some variants...

https://thesicktimes.org/2025/08/12/no-easy-home-runs-early-long-covid-trials-of-paxlovid-and-monoclonal-antibodies-failed-but-the-treatments-still-have-potential/

Viral spike antigen clearance and augmented recovery in children with post-COVID multisystem inflammatory syndrome treated with larazotide Lael M. Yonker, Abigail S. Kane, Zoe Swank, Lena Papadakis, Victoria Kenyon, Samuel Han, Rosiane Lima, Lauren B. Guthrie, Bryan Alvarez-Carcamo, Manuella...

Possible long COVID biomarker: identification of SARC-CoV-2 related protein(s) in Serum Extracellular Vesicles Asghar Abbasi, Ritin Sharma, Nathaniel Hansen, Patrick Pirrotte & William W. Stringer [Snippets from correspondence with no abstract, bolding added] Web | PDF | Infection | Open...

Long Vax is delayed onset Long COVID Thomas Bunker [Line breaks added] Highlights • Long Vax or PCVS is a large constellation of chronic patient-reported symptoms that closely align with those of Long COVID. • SARS-CoV-2 actively suppresses pathogen sensing pathways within infected...

COVID-19 induces persistent transcriptional changes in adipose tissue that are not associated with Long COVID Soneida DeLine-Caballero; Kalani Ratnasiri; Heping Chen; Seynt Jiro Sahagun; Uma M. Mangalanathan; Trisha R. Barnard; Nicole Turk; Jasmine Yang; Natesh Saini; Ekrem M. Ayhan; Hasiyet...

The Role of SARS-CoV-2 Nucleocapsid Protein Persistence in Inducing Chronic Type I Interferon and Mitochondrial Dysfunction. Andreas Koenig; Mohammad Quasem; Benjamin Zink; Doniyorbek Abdulla-Zoda; Priyanka Karunanidhi; Karolina Sienko; Christian Geier; Venkatesh Jayaraman; Rabia Malik; Kanza...

Characteristic immune cell interactions in livers of children with acute hepatitis revealed by spatial single-cell analysis identify a possible postacute sequel of COVID-19 Felix Röttele; Andreas Zollner; Carolin Mogler; Muhammed Yuksel; Cigdem Arikan; Vivien Karl; Judith Helene Aberle; Stephan...

Spatial transcriptomics of the epipharynx in long COVID identifies SARS-CoV-2 signalling pathways and the therapeutic potential of epipharyngeal abrasive therapy Kensuke Nishi, Shohei Yoshimoto, Takayuki Tanaka, Shoichi Kimura, Toshiyuki Tsunoda, Akira Watanabe, Kaori Teranaka, Yo Oguma, Hanako...

947 – Post-Acute SARS-CoV-2 Antigenemia Is Associated With Some but Not All Long COVID Symptoms Michael Peluso, Thomas Dalhuisen, Zoe Swank, Sarah Goldberg, Scott Lu, Samuel Han, Jessica Chen, Emily Fehrman, Khamal Anglin, Rebecca Hoh, Timothy J. Henrich, Dan Kelly, Steven G. Deeks, David Walt...

937 – Lack of Association of SARS-CoV-2 N- and S-Antigenemia With Long COVID Annukka Antar, Perrine Lallemand, Zoe O. Demko, Armaan Jamal, Nuria Gallego Marquez, Tamilore Adeagbo, Selin Akbas, Elizabeth Pasetes, Paul Blair, Katy Shaw-Saliba, Andrea Cox, Michael Peluso, Robin Dewar, Alan Landay...