vaccination

Single-cell-resolved dynamic immune remodeling following Omicron infection and recovery in vaccinated individuals Abstract Breakthrough SARS-CoV-2 Omicron infections occur despite vaccination, yet post-infection immune recovery remains incompletely understood. Here, we performed longitudinal...

Abstract: Introduction Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating multisystem disorder associated with immune dysregulation yet lacks definitive biomarkers or effective therapies. Acute immune perturbations may transiently modulate disease manifestations...

https://www.science.org/doi/10.1126/science.aea7733 Introduction Vaccination is a critical tool for global public health, but wide variability in human vaccine responses influences vaccine effectiveness. Vaccine adverse reactions, including common side effects such as fever and flu-like...

COVID-19 infection raises respiratory type 2 inflammatory disease risk, whereas vaccination is protective Abstract Background Coronavirus disease 2019 (COVID-19) infection and vaccination have unclear impacts on type 2 inflammatory diseases. Although viral infections can drive immune...

Association of mRNA SARS-CoV-2 vaccination with fatigue and functional recovery in patients with post-acute sequelae of COVID-19 (PASC) Background Patients with post-acute sequelae of SARS-CoV-2 (PASC) fear SARS-CoV-2 vaccine-linked symptom aggravation. Data on objective functional outcomes...

Annual vaccination with BNT162b2 in Germany can avoid substantial clinical and economic burden of COVID-19 disease Abstract Aims To quantify the clinical and economic burden of Coronavirus disease 19 (COVID-19), and burden potentially avoided with annual vaccination, in German adults in an...

Improvement of post-COVID-19 vaccination dysautonomia with GLP-1 receptor agonist Abstract Vasovagal syncope (VVS) is the most common form of cardiovascular dysautonomia that has multiple etiologies. Post-vaccination dysautonomia, in the form of VVS and postural orthostatic tachycardia...

COVID-19 Vaccine Effectiveness and Safety for the 2026-2027 Respiratory Season Abstract Importance SARS-CoV-2 remains a substantial cause of respiratory illness, morbidity, and mortality. Evidence to date has demonstrated that COVID-19 vaccines reduce the risk of severe disease, including...

Long COVID symptom trajectories according to post-COVID-19 vaccination status: a prospective longitudinal study Abstract Long COVID remains a substantial public health challenge, and the relationship between post-COVID-19 vaccination and symptom persistence remains uncertain. This prospective...

Acute symptoms and subsequent post-acute symptoms following COVID-19 vaccination: A Danish population-based study Objectives Acute symptoms are common following COVID-19 vaccination, yet it remains unclear if these reactions can manifest or progress into non-specific symptoms (e.g., headache...

Beneficial Effect of COVID-19 Vaccination on Decreased Pulmonary Vascular and Airway Volumes of Patients with Long-COVID Syndrome BACKGROUND Despite normal lung imaging and preserved pulmonary and cardiac function, many patients with long COVID continue to experience persistent respiratory...

COVID-19 vaccination timing, relative to acute COVID-19, and subsequent risk of long COVID Summary Background Vaccination is a vital tool in preventing acute COVID-19 and may confer additional protection against Long COVID, although it is unclear whether this protection wanes over time...

Immune correlates underlying small fiber neuropathy presenting as vaccine-associated post-acute SARS- coronavirus syndrome BACKGROUND A spectrum of adverse events overlapping with Post-acute Sequelae of SARS-CoV-2 infection (PASC) occurs in some patients following SARS-CoV-2 vaccination...

Persistent class switch toward spike-specific IgG4 antibodies after repeated SARS-CoV-2 mRNA vaccination in post-acute infection syndrome: an exploratory cohort study Ana M. Espino, Carlimar Ocasio-Malavé, Riseilly Ramos, Ramon Sanmartin, Jesus Castro-Marrero Abstract Myalgic...

Autoimmune Disease is Associated with Heightened Long COVID Risk but Prior Immunization is Protective Objectives Patients with autoimmune disease (AD) may be predisposed to Long COVID, yet the impact of primary autoantibody-associated AD and prior immunization remains unclear. Methods...

Adenoviral Inciting Antigen and Somatic Hypermutation in VITT BACKGROUND Vaccine-induced immune thrombocytopenia and thrombosis (VITT) is a rare prothrombotic complication that occurs after adenoviral vector–based vaccination against coronavirus disease 2019; in rare cases, it can also occur...

Immunological Density Shapes Recovery Trajectories in Long COVID [Line breaks added] Abstract Post-acute sequelae of SARS-CoV-2 infection (Long COVID) frequently persists for months, yet drivers of clinical remission remain incompletely defined. Here we analyzed 97,564 longitudinal PASC...

Complex chronic adverse events following immunization: a systemic critique and reform proposal for vaccine pharmacovigilance Tiff-Annie Kenny The COVID-19 pandemic has renewed attention to complex chronic health conditions that challenge conventional biomedical paradigms. Syndromes such as...

Patterns of long COVID symptoms among healthcare workers in the UK and variations by sociodemographic, clinical and occupational factors: a cross-sectional analysis of a nationwide study UK-REACH OBJECTIVES This study aimed to examine symptom patterns between healthcare workers (HCWs) with and...

Asymptomatic infection in a proof-of-concept longitudinal study on SARS-CoV-2 vaccine recipients Individuals with asymptomatic SARS-CoV-2 infection can unknowingly transmit the virus, yet identifying such infections in vaccinated populations remains challenging. We conducted a longitudinal...