sphingomyelin

A research perspective on sphingolipid metabolism and myalgic encephalomyelitis/chronic fatigue syndrome Xiao, Junhua No abstract. Link | PDF (Neural Regeneration Research)

Abstract: We proposed that cerebrospinal fluid would provide objective evidence for disrupted brain metabolism in myalgic encephalomyelitis/chronic fatigue syndroome (ME/CFS). The concept of postexertional malaise (PEM) with disabling symptom exacerbation after limited exertion that does not...

Highlights •FM patients have higher anti-SGC IgG levels associated with pain intensity •FM patients have lower levels of phospholipid classes, sphingomyelin, and triglycerides •FM patients have higher levels of diglycerides •FM severe have higher levels of some lysophosphatidylcholines than FM...

Katherine Huang, Alex G. C. de Sá, Natalie Thomas, Robert D. Phair, Paul R. Gooley, David B. Ascher & Christopher W. Armstrong Abstract Background Diagnosing complex illnesses like Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is complicated due to the diverse symptomology and...

Anti-Nociceptive Effects of Sphingomyelinase and Methyl-Beta-Cyclodextrin in the Icilin-Induced Mouse Pain Model Horváth, Ádám; Steib, Anita; Nehr-Majoros, Andrea; Kántás, Boglárka; Király, Ágnes; Racskó, Márk; Tóth, Balázs István; Szánti-Pintér, Eszter; Kudová, Eva; Skoda-Földes, Rita; Helyes...

Plasma Instead of Serum Avoids Critical Confounding of Clinical Metabolomics Studies by Platelets Gerhard Hagn; Samuel M. Meier-Menches; Günter Plessl-Walder; Gaurav Mitra; Thomas Mohr; Karin Preindl; Andreas Schlatter; Doreen Schmidl; Christopher Gerner; Gerhard Garhöfer; Andrea Bileck...

The role of Sphingolipids in myelination and myelin stability and their involvement in childhood and adult demyelinating disorders Paola Giussani; Alessandro Prinetti; Cristina Tringali Multiple sclerosis (MS) represents the most common demyelinating disease affecting the central nervous system...

Sphingolipids and their metabolism in physiology and disease Hannun, Yusuf A.; Obeid, Lina M. Studies of bioactive lipids in general and sphingolipids in particular have intensified over the past several years, revealing an unprecedented and unanticipated complexity of the lipidome and its many...

Alterations to Sphingomyelin Metabolism Affect Hemostasis and Thrombosis Jue Wang; Shiva Keshava; Kaushik Das; Richard Kolesnick; Xian-Cheng Jiang; Usha R. Pendurthi; L. Vijaya Mohan Rao BACKGROUND: Our recent studies suggest that sphingomyelin levels in the plasma membrane influence TF (tissue...

Impact of sphingolipids on protein membrane trafficking Aguilera-Romero; Lucena; Sabido-Bozo; Muñiz Membrane trafficking is essential to maintain the spatiotemporal control of protein and lipid distribution within membrane systems of eukaryotic cells. To achieve their functional destination...

Circulating Metabolome and White Matter Hyperintensities in Women and Men Eeva Sliz; Jean Shin; Shahzad Ahmad; Dylan M. Williams; Stefan Frenzel; Friederike Gauß; Sarah E. Harris; Ann-Kristin Henning; Maria Valdes Hernandez; Yi-Han Hu; Beatriz Jiménez; Muralidharan Sargurupremraj; Carole Sudre...

A global lipid map reveals host dependency factors conserved across SARS-CoV-2 variants Farley, Scotland E.; Kyle, Jennifer E.; Leier, Hans C.; Bramer, Lisa M.; Weinstein, Jules B.; Bates, Timothy A.; Lee, Joon-Yong; Metz, Thomas O.; Schultz, Carsten; Tafesse, Fikadu G. A comprehensive...

A novel estrogen receptor 1: sphingomyelin phosphodiesterase acid-like 3B pathway mediates rituximab response in myositis patients Parkes, Joanna E; Boehler, Jessica F; Li, Ning; Kendra, Ryan M; O’Hanlon, Terrance P; Hoffman, Eric P; Peterson, Jennifer M; Miller, Frederick W; Rider, Lisa G...

The Lipid-Modifying Enzyme SMPDL3B Negatively Regulates Innate Immunity Heinz; Baumann; Köberlin; Snijder; Gawish; Shui; Sharif; Aspalter; Müller; Kandasamy; Breitwieser; Pichlmair; Bruckner; Rebsamen; Blüml; Karonitsch; Fauster; Colinge; Bennett; Knapp; Superti-Furga Lipid metabolism and...

Introduction: Similar to what it has been reported with preceding viral epidemics (such as MERS, SARS, or influenza), SARS-CoV-2 infection is also affecting the human immunometabolism with long-term consequences. Even with underreporting, an accumulated of almost 650 million people have been...

Immunometabolic rewiring in long COVID patients with chronic headache Suan-Sin Foo, Weiqiang Chen, Kyle L Jung, Tamiris Azamor, Un Yung Choi, Pengfei Zhang, Suzy AA Comhair, Serpil C Erzurum, Lara Jehi, Jae U Jung Almost 20% of patients with COVID-19 experience long-term effects, known as...

Threads for the preprint and final paper have ben merged. Abstract for the final paper here. PREPRINT Evidence for Peroxisomal Dysfunction and Dysregulation of the CDP-Choline Pathway in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Xiaoyu Che, Christopher R Brydges, Yuanzhi Yu, Adam...

Study now printed, see https://www.s4me.info/threads/preprint-multi-omics-of-host-microbiome-interactions-in-short-and-long-term-myalgic-encephalomyelitis-chronic-fatigue-syndrome-me-cfs-2021-xiong.23022/#post-459931 for abstract and link Preprint: Multi-omics of host-microbiome interactions in...

This is the latest work of Dr Naviaux and colleagues on cell-danger response, on mice. Metabolic and behavioral features of acute hyperpurinergia and the maternal immune activation mouse model of autism spectrum disorder Abstract Since 2012, studies in mice, rats, and humans have suggested...