small fiber neuropathy

Autonomic function testing and symptom severity in patients with suspected mast cell activation disorders We assessed both objective and subjective measures of autonomic severity in patients with formally classified mast cell activation disorder (MCAD), hereditary alpha tryptasemia (HaT), and...

Autoantibodies mediate pain and sensory dysfunction in post-COVID syndrome Pain and fatigue are common but poorly understood features of post-COVID Syndrome (PCS). To probe the mechanistic basis of these symptoms, we investigated sensory functions in patients with widespread pain attributed to...

Abstract Background Cardiovascular autonomic disorders (CAD) were described following COVID-19 infection and vaccination, but previous reports were limited in size and follow-up. Here, we aimed to investigate the type and frequency of newly diagnosed and exacerbated CAD following COVID-19...

3603 Multimodal non-invasive neurophysiological testing of small fibre neuropathy in long COVID Anthony Khoo, Kisani Manuel, David Lynn, Maria Crotty Background Long COVID is associated with a diverse range of debilitating neuropathic and autonomic symptoms that may indicate small fibre...

Microneurography Reveals Unmyelinated Small Nerve Fiber Dysfunction in Long COVID OBJECTIVE To review the microneurography findings of long coronavirus disease 2019 (COVID) patients who presented to the clinic with multisystem involvement affecting neurological, cardiovascular...

Abstract Aim Postural orthostatic tachycardia syndrome (POTS) is a disorder with cardiovascular autonomic dysfunction where multiple and variable symptoms are common, including those from the peripheral and enteric nervous systems. We aimed to investigate subjective and objective signs of small...

Long-COVID Postural Tachycardia Syndrome: A deep phenotyping study Nicholas W Larsen; Jannika V Machnik; Jordan Seliger; Ruba Shaik; Christopher H Gibbons; Paul J Utz; Maarten G Lansberg; Srikanth Muppidi; Safwan Jaradeh; Mitchell G Miglis BACKGROUND Postural tachycardia syndrome (POTS) has...

Analysis of 977 Long COVID Patients Reveals Prevalent Neuropathy and Association with Anti-Ganglioside Antibodies Cole Maguire; Kristina Kashyap; Elizabeth Williams; Aziz Rija; Maisey Schuler; Cheyenne Ahamed; Chumeng Wang; Aurelia Mena; Jeffrey Saniuk; Johanna Busch; Sara Austin; Mary Kelley...

research from Singapore… @Jonathan Edwards? paywall for me. https://www.jni-journal.com/article/S0165-5728(25)00039-6/abstract Efficacy of rituximab on antibody-positive small fiber neuropathy: A series of 5 cases Results Two patients were positive for anti-TS-HDS, one for anti-plexin D1...

Post-COVID-19 Small Fiber Neuropathy as a New Emerging Quality of Life-Threatening Disease: A Systematic Review Francesca Bandinelli, Marco Di Carlo, Virginia Alba Colantuono, Filippo Nozzoli, Fausto Salaffi, Barbara Chiocchetti, Elena Nucci, Alessandra Mastricci, Eleonora Gherardi, Mirko...

I was diagnosed with small fiber neuropathy via skin biopsy. I'm trying to understand my health issues and I'm wondering if it's possible to have a painless form of SFN that presents with fatigue, poor sleep, exertion intolerance, mild intolerance of upright position. I later developed more...

Small fiber neuropathy in the post-COVID condition and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Clinical significance and diagnostic challenges Naiara Azcue; Sara Teijeira-Portas; Beatriz Tijero-Merino; Marian Acera; Tamara Fernández-Valle; Unai Ayala; Maitane Barrenechea; Ane...

Association Between NK Cell Genetic Variants and the Development of Long COVID Associated- and Prepandemic Small Fiber Neuropathy Marianne Graninger; Verena Endmayr; Laura M. Kühner; Sarah M. Berger; Paulus Rommer; Sigrid Klotz; Ellen Gelpi; Hannes Vietzen; Romana Höftberger; Elisabeth...

I found this interesting because it claims that in small fiber neuropathy, most patients had intense fatigue, myalgia, and subjective weakness and lower intensity of neuropathic pain. https://www.medrxiv.org/content/10.1101/2024.09.09.24313341v1.full.pdf

Relapsing-Remitting Immunotherapy Responsive Small-Fiber Neuropathy Anne Louise Oaklander, Julia Allen, Nadja Dietliker, Einar P. Wilder-Smith OBJECTIVES To expand understanding of the pathogenesis, presentations, and treatment of initially idiopathic small fiber polyneuropathy (SFN). METHODS...

Broadening the Genetic Spectrum of Painful Small-Fiber Neuropathy through Whole-Exome Study in Early-Onset Cases Misra, Kaalindi; Ślęczkowska, Milena; Santoro, Silvia; Gerrits, Monique M.; Mascia, Elisabetta; Marchi, Margherita; Salvi, Erika; Smeets, Hubert J. M.; Hoeijmakers, Janneke G. J...

A clinical geneticist believes that a rare variant in the SCN9A gene could be responsible for at least a part of my symptoms. The variant is extremely rare (1 in 1.4 million alleles) and not found in healthy people. The gene is associated with small fibre neuropathy which would fit, but there...

Full title: Validation of symptom measures in patients under investigation for postural orthostatic tachycardia syndrome (POTS): The Orthostatic Grading Scale (OGS) and the Symptom Screen for Small-fiber Polyneuropathy (SSS) Highlights More standardized symptom reporting is needed in Postural...

I recieved this newsletter and could not find it posted on the Internet, so I thought I’d post the text. This is a newsletter from a small company, Winsantor, who is testing a topical drug (WST-057) to see if it increases small fiber nerve density (and improve symptoms?) in diabetic patients...

3 Years Into Long COVID: Where Do We Go From Here? https://www.medscape.com/viewarticle/993827 "... approximately 6% of all US adults are currently experiencing long COVID, with Hispanic/Latinx individuals, transgender individuals, and cis female individuals facing the highest rates."...