sickness behaviour

Link Highlights • Viruses induce depressive behavior and ISG15 expression at the blood-brain barrier • IFNAR1 expression on neural cells is not involved in IFN-β-induced sickness behavior • IFNAR1 expression on brain endothelial and epithelial cells drives behavioral changes • Brain...

I have mentioned elsewhere that I describe PEM as being like having the flu, or another significant infection. I think there are studies that show that cognition is negatively affected during an acute infection, and I don't think it is just the distraction of pain. And I think there are...

Effects of a mild inflammatory challenge on cytokines and sickness behavior: A randomized controlled trial using the influenza vaccine Jolink; Feldman; Antenucci; Cardenas; West; Nakamura; Muscatell The influenza vaccine has reliably been associated with mild, within-person increases in...

The neuroimmune connectome in health and disease Wheeler, Michael A.; Quintana, Francisco J. The nervous and immune systems have complementary roles in the adaptation of organisms to environmental changes. However, the mechanisms that mediate crosstalk between the nervous and immune systems...

Abstract: Everyone knows that an infection can make you feel sick. Although we perceive infection-induced changes in metabolism as a pathology, they are a part of a carefully regulated process that depends on tissue-specific interactions between the immune system and organs involved in the...

Abstract Pathogen infection causes a stereotyped state of sickness that involves neuronally orchestrated behavioural and physiological changes1,2. On infection, immune cells release a ‘storm’ of cytokines and other mediators, many of which are detected by neurons3,4; yet, the responding neural...

A preoptic neuronal population controls fever and appetite during sickness Osterhout, Kapoor, Eichhorn, Vaughn, Moore, Ding Liu, Lee, DeNardo, Liqun Luo, Xiaowei Zhuan, Dulac Abstract During infection, animals exhibit adaptive changes in physiology and behaviour aimed at increasing...

This book represents the papers delivered at the international conference on Illness Behavior held in Toronto in 1985. It should not be considered out of date. It was reprinted in 2013 and so it must be assumed that it is still used either for teaching material or by practitioners. Illness...

Open access, https://journals.sagepub.com/doi/10.1177/1049732320969395

This isn't biomedical research so I posted it here.

How to explain the evolutionary advantages of Sickness Behavior. This article is from 2015. Maybe the scientific frontier has advanced since. Anyone knows? Anyway: I'm a bit impressed. :) Source: https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.1002276

You will, from time to time, have seen references to "abnormal illness behaviour" in connection with ME or CFS, and these will no doubt have cited the various papers by Mechanic on the subject of "illness behaviour". It seems that this is not quite the full story. There appears to be a lacuna...

Sickness behaviour is a concept that's often referred to in relation to MECFS. I want to see what people think of it. Whether there's something in it, or whether its just a tool used by the mind-over-body crowd. Here's a rough intro to the concept: Sickness behaviour refers to the behavioural...