Shisa6 traps AMPA receptors at postsynaptic sites and prevents their desensitization during synaptic activity
Trafficking and biophysical properties of AMPA receptors (AMPARs) in the brain depend on interactions with associated proteins. We identify Shisa6, a single transmembrane protein, as a...
The locus near SHISA6 wasn't quite genome-wide significant, but it was close at p=8.26e-08.
From GeneCards:
Here is a plot of this locus (LocusZoom link):
Edit: The lead variant at this locus is: 17:11,325,637:G:C / rs1546559
Abstract
Background
Postural orthostatic tachycardia syndrome (POTS) is a complex disorder with serious health consequences, while its etiology remains largely elusive.
Objective
The purpose of this study was to investigate the genetic landscape of POTS using genomic approaches in a unique...
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