schizophrenia

Mapping the genetic landscape across 14 psychiatric disorders Psychiatric disorders display high levels of comorbidity and genetic overlap1,2, challenging current diagnostic boundaries. For disorders for which diagnostic separation has been most debated, such as schizophrenia and bipolar...

Abstract Rare genetic factors have been shown to substantially contribute to mental illness, but so far, no precision treatments for mental disorders have been described. It was recently identified that rare variants in GRIN2A encoding the GluN2A subunit of the N-methyl-D-aspartate receptor...

Doxycycline Use in Adolescent Psychiatric Patients and Risk of Schizophrenia: An Emulated Target Trial American Journal of Psychiatry https://psychiatryonline.org/doi/10.1176/appi.ajp.20240958 Paywalled Objective: As many as half of individuals who develop psychosis had attended child and...

Schizophrenia, Bipolar, or Major Depressive Disorder and Postacute Sequelae of COVID-19 IMPORTANCE Given the increased vulnerability to COVID-19 among those with a serious mental illness (SMI), it remains unclear whether these individuals face a higher risk of developing postacute sequelae of...

Dysregulated oxidative stress and lactate levels in treatment-resistant schizophrenia Fang; Zhang; Xu; Wang; He; Liao; Yuan; Tang Schizophrenia is a severe and clinically heterogeneous mental disorder, with approximately 30 % of patients developing treatment resistance to standard...

Gene discovery and biological insights into anxiety disorders from a large-scale multi-ancestry genome-wide association study Eleni Friligkou, Solveig Løkhammer, Brenda Cabrera-Mendoza, Jie Shen, Jun He, Giovanni Deiana, Mihaela Diana Zanoaga, Zeynep Asgel, Abigail Pilcher, Luciana Di Lascio...

Albuminuria and Mental Illness Risk: Results From National Health and Nutrition Examination Survey 2005–2018 and Mendelian Randomization Analyses Yangyang Wang, Sen Li [Line breaks added] Background Recent evidence suggests a link between albuminuria and mental illness. However, whether this...

The hypothesis of biologically based subtypes of schizophrenia: a 10-year update Oliver D. Howes, Bernard R. Bukala, Sameer Jauhar, Robert A. McCutcheon [First paragraph with line break added:] A decade ago we proposed that there are two biological subtypes of schizophrenia: type A...

Immunological drivers and potential novel drug targets for major psychiatric, neurodevelopmental, and neurodegenerative conditions Christina Dardani, Jamie W. Robinson, Hannah J. Jones, Dheeraj Rai, Evie Stergiakouli, Jakob Grove, Renee Gardner, Andrew M. McIntosh, Alexandra Havdahl, Gibran...

Toxoplasma gondii as a Causal Factor in Schizophrenia: Evidence from Two Large Cohorts Ariel Israel, Avi Weizman, Sarah Israel, Joshua Stokar, Shai Ashkenazi, Shlomo Vinker, Eli Magen, Eugene Merzon Background Schizophrenia (SCZ) is a debilitating psychiatric disorder with a complex and poorly...

Molecular overlaps of neurological manifestations of COVID-19 and schizophrenia from a proteomic perspective Antunes, André S. L. M.; Reis-de-Oliveira, Guilherme; Martins-de-Souza, Daniel COVID-19, a complex multisystem disorder affecting the central nervous system, can also have psychiatric...

SARS-CoV-2 Infection is Associated with an Increase in New Diagnoses of Schizophrenia Spectrum and Psychotic Disorder: A Study Using the US National COVID Cohort Collaborative N3C Asif Rahman; Michael Russell; Wanhong Zheng; Daniel Eckrich; Imtiaz Ahmed; on behalf of the N3C Consortium Amid the...

Prioritization of potential causative genes for schizophrenia in placenta https://www.nature.com/articles/s41467-023-38140-1 Abstract Our earlier work has shown that genomic risk for schizophrenia converges with early life complications in affecting risk for the disorder and sex-biased...

Sex differences in the blood-brain barrier: Implications for mental health Dion-Albert L, Bandeira Binder L, Daigle B, Hong-Minh A, Lebel M, Menard C Prevalence of mental disorders, including major depressive disorder (MDD), bipolar disorder (BD) and schizophrenia (SZ) are increasing at...

Thread or here https://typefully.com/doctorveera/BZevgUj

Comer Ashley L., Carrier Micaël, Tremblay Marie-Ève, Cruz-Martín Alberto (2020), The Inflamed Brain in Schizophrenia: The Convergence of Genetic and Environmental Risk Factors That Lead to Uncontrolled Neuroinflammation, Frontiers in Cellular Neuroscience 14 (2020), DOI...

In a new blog series, we will investigate how illnesses were once thought to result from stress, psychological disturbance, or deviant personality features. From the cancer-prone personality to the theory of ‘refrigerator mothers’, medicine appears to suffer from a recurrent tendency to...

Abstract The importance of tryptophan as a precursor for neuroactive compounds has long been acknowledged. The metabolism of tryptophan along the kynurenine pathway and its involvement in mental disorders is an emerging area in psychiatry. We performed a meta-analysis to examine the...

Full title: Chronic fatigue and fibromyalgia symptoms are key components of deficit schizophrenia and are strongly associated with activated immune-inflammatory pathways I'd suggest that there is total conflation between chronic fatigue and 'chronic fatigue syndrome' here. Paywall...

Pre-print: https://www.preprints.org/manuscript/202003.0432/v1 Chronic Fatigue Syndrome and Fibromyalgia-Like Symptoms Are an Integral Component of the Phenome of Schizophrenia: Neuro-Immune and Opioid System Correlates