sars-cov-2

Multi-layered deep immune profiling, SARS-CoV-2 RNAemia and inflammation in unvaccinated COVID-19 individuals with persistent symptoms Roberta Rovito, Valeria Bono, Nicolò Coianiz, Valentina Cazzetta, Sara Franzese, Joanna Mikulak, Clara Di Vito, Francesca Bai, Guillaume Beaudoin-Bussières...

Spatial transcriptomics of the epipharynx in long COVID identifies SARS-CoV-2 signalling pathways and the therapeutic potential of epipharyngeal abrasive therapy Kensuke Nishi, Shohei Yoshimoto, Takayuki Tanaka, Shoichi Kimura, Toshiyuki Tsunoda, Akira Watanabe, Kaori Teranaka, Yo Oguma, Hanako...

Abstract In a subset of children and adolescents, SARS-CoV-2 infection induces a severe acute hyperinflammatory shock1 termed multisystem inflammatory syndrome in children (MIS-C) at four to eight weeks after infection. MIS-C is characterized by a specific T cell expansion2 and systemic...

Double-seropositive Myasthenia Gravis Following COVID-19: A case report Yuki Hiraoka, Yasushi Hosoi, Takuya Tsubata, Miharu Yanagida, Yusuke Otake, Michiko Ito [Line breaks added] Abstract Myasthenia gravis (MG) is an autoimmune disease characterized by muscle weakness caused by antibodies...

Role of antiviral CD8+ T cell immunity to SARS-CoV-2 infection and vaccination Vivien Karl, Maike Hofmann, Robert Thimme [Line breaks added] Abstract The COVID-19 pandemic has greatly enhanced our understanding of CD8+ T cell immunity and their role in natural infection and vaccine-induced...

Molecular architecture of coronavirus double-membrane vesicle pore complex Yixin Huang, Tongyun Wang, Lijie Zhong, Wenxin Zhang, Yu Zhang, Xiulian Yu, Shuofeng Yuan & Tao Ni [Line breaks added] Abstract Coronaviruses remodel the intracellular host membranes during replication, forming...

Abstract COVID-19 vaccines have prevented millions of COVID-19 deaths. Yet, a small fraction of the population reports a chronic debilitating condition after COVID-19 vaccination, often referred to as post- vaccination syndrome (PVS). To explore potential pathobiological features associated with...

Sex-related differences in the association between migraine, COVID-19, and long COVID: A population-based cohort Linda Al-Hassany, Antoinette - MaassenVanDenBrink, Tobias Kurth [Line breaks added] Abstract Coronavirus disease 2019 (COVID-19), caused by the SARS-CoV-2 virus, placed...

Amyloid-forming potential of Betacoronavirus including SARS-CoV-2 Hazem Haddad, Walid Al-Zyoud Abstract Prions are considered as sub-viral protein particles that have exceptional ability for multiple structural or functional conformational changes, leading to amyloid or prion forming or...

SARS-COV-2 re-infection and incidence of post-acute sequelae of COVID-19 (PASC) among essential workers in New York: a retrospective cohort study https://www.thelancet.com/journals/lanam/article/PIIS2667-193X(24)00311-9/fulltext Background After surviving Coronavirus Disease 2019 (COVID-19)...

Evaluation of off-label rapamycin use to promote healthspan in 333 adults Tammi L Kaeberlein, Alan S Green, George Haddad, Johnny Hudson, Anar Isman, Andy Nyquist, Bradley S Rosen, Yousin Suh, Sajad Zalzala, Xingyu Zhang, Mikhail V Blagosklonny, Jonathan Y An, Matt Kaeberlein Abstract...

Objectives Long COVID-19 (LC) patients experience a number of chronic idiopathic symptoms that are highly similar to those of post-viral Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). We have therefore performed a systematic review and meta-analysis to determine the proportion of...

Summary Long COVID, a type of post-acute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (PASC) defined by medically unexplained symptoms following infection with SARS-CoV-2, is a newly recognized infection-associated chronic condition that causes disability in some...

I'm spending more time indoors and want more protection against the virus. A few years ago nasal sprays were claimed to be effective against the virus, either by creating a protective barrier or killing the virus. Was this hype and marketing or is it true? What's the sentiment on this forum...

Highlights • Persistent symptoms were greater following the first SARS-CoV-2 infection. • The most frequent persistent symptoms were fatigue, tiredness and shortness of breath. • Proportion of persistent symptoms varied by variant of infection. • A reduction of persistent symptoms after COVID-19...

Abstract Introduction: The relationship between SARS-CoV-2 viral dynamics during acute infection and the development of long COVID is largely unknown. Methods: A total of 7361 asymptomatic community-dwelling people enrolled in the Test Us at Home parent study between October 2021 and February...

https://pubmed.ncbi.nlm.nih.gov/38808863/ Abstract Background: Over 30% of patients with COVID-19 have persistent symptoms that last beyond 30 days and referred to as Long COVID. Long COVID has been associated with a persistent elevation in peripheral cytokines including interleukin-6...

[I think this belongs here - please move if necessary] A Fight About Viruses in the Air Is Finally Over. Now It’s Time for Healthy Venting https://www.scientificamerican.com/article/a-fight-about-viruses-in-the-air-is-finally-over-now-its-time-for-healthy/

An amyloidogenic fragment of the SARS CoV-2 envelope protein promotes serum amyloid A misfolding and fibrillization Asal Nady; Sean E Reichheld; Simon Sharpe SARS CoV-2 infection can affect a surprising number of organs in the body and cause symptoms such as abnormal blood coagulation...

The S1 subunits of SARS-CoV-2 variants differentially trigger the IL-6 signaling pathway in human brain endothelial cells and downstream impact on microglia activation Michael Stangis; Daniel Adesse; Bhavya Sharma; Eduardo Castro; Kush Kumar; Neil Kumar; Masha Minevich; Michal Toborek...