risk factors

Whole genome sequence meta-analyses reveal common and rare genetic associations with critical COVID-19 In susceptible patients, COVID-19 causes life-threatening disease driven by immune-mediated inflammatory lung injury. We have previously shown that multiple common host genetic variants are...

Vitamin D intake and multiple sclerosis risk in the Norwegian Mother, Father and Child cohort BACKGROUND Higher vitamin D has consistently been associated with a lower multiple sclerosis (MS) risk, but some controversy remains about whether this is due to vitamin D itself or sunlight. METHODS...

Metformin at the time of Covid-19 infection and risk of Long Covid: A Target Trial Emulation Study BACKGROUND Our objective was to evaluate metformin prescribed at the time of SARS-CoV-2 infection on the risk of developing Long Covid (LC) in electronic health record data. METHODS We conducted...

Pre-pandemic lifestyle patterns and mental health outcomes among people reporting post-acute sequelae of COVID-19: evidence from a Slovenian population-based sample BACKGROUND The long-term consequences of COVID-19, or post-acute sequelae of SARS-CoV-2 infection (PASC), represent a major...

https://www.sciencedirect.com/science/article/pii/S0264410X25012046 Abstract Purpose In adolescents (12–17 years), it is unknown whether COVID-19 vaccination reduces progression from COVID-19 to Long COVID (LC) beyond preventing SARS-CoV-2 infection. We assessed the effect of vaccination...

Exploring predictors of post-COVID-19 condition among 810 851 individuals in Sweden BACKGROUND Long-term effects of COVID-19 can place burden on individuals, healthcare, and society. We aimed to evaluate the importance of a wide range of potential risk factors for being diagnosed with...

Schizophrenia, Bipolar, or Major Depressive Disorder and Postacute Sequelae of COVID-19 IMPORTANCE Given the increased vulnerability to COVID-19 among those with a serious mental illness (SMI), it remains unclear whether these individuals face a higher risk of developing postacute sequelae of...

Pre-pandemic disease trajectories and genetic insights into long COVID susceptibility BACKGROUND Long COVID refers to the persistence of symptoms after SARS-CoV-2 infection. While individual comorbidities have been studied, the role of coexisting chronic conditions remains underexplored. This...

https://pubmed.ncbi.nlm.nih.gov/41080863/ Abstract Introduction: During the COVID-19 pandemic, between 12 and 20% of US adults were identified as having post-COVID-19 condition, commonly referred to as 'Long COVID'. These individuals maintained symptoms of COVID-19 for 3 months or longer...

Genetic Risk Variants for Multiple Sclerosis and Other Loci Linked to Intrathecal Immunoglobulin G Synthesis BACKGROUND AND OBJECTIVES Intrathecal synthesis of immunoglobulin G (IgG) is a key feature of multiple sclerosis (MS) and a prognostic marker for the disease course. Although previous...

Long COVID After Acquisition of the Omicron Variant of Severe Acute Respiratory Syndrome Coronavirus 2 SARS-CoV-2 During Pregnancy Compared With Outside of Pregnancy OBJECTIVE To evaluate whether the risk of long COVID among individuals infected with severe acute respiratory syndrome...

Associations of selective serotonin reuptake inhibitors and long COVID risk in patients with depression: a retrospective cohort study PURPOSE To evaluate the potential of selective serotonin reuptake inhibitors (SSRIs) in reducing the risk of long COVID in patients with depression. METHODS...

Incidence of Long COVID Following Reinfection with COVID-19 M Daniel Brannock; Emily Hadley; Alexander Preiss; Megan L Fitzgerald; Nita Jain; Emily Taylor; Andrew Wylam; Yun J Yoo; Elaine Hill; Richard A Moffitt; N3C Consortium; RECOVER Consortium BACKGROUND COVID-19 reinfections have emerged...

Pre-COVID health-related quality of life predicts symptoms and outcomes for patients with long COVID Lapin, Brittany; Baker, Samantha; Thompson, Nicolas; Li, Yadi; Milinovich, Alex; Lago, William; Katzan, Irene BACKGROUND Post-acute sequelae SARS-CoV-2 (PASC) is a prevalent condition with...

Social Determinants of Health and Risk for Long COVID in the U.S. RECOVER-Adult Cohort BACKGROUND Social determinants of health (SDoH) contribute to disparities in SARS-CoV-2 infection, but their associations with long COVID are unknown. OBJECTIVE To determine associations between SDoH at the...

Background Fatigue is a common sequela of SARS-CoV-2 infection, with many COVID-19 patients subsequently developing chronic fatigue syndrome and myalgic encephalomyelitis (CFS/ME). Long-term associations between COVID-19, new-onset CFS/ME, and other independent predictors such as vaccination for...

Decreased risk of chronic fatigue syndrome following influenza vaccine: a 20-year population-based retrospective study Chang, Hsun; Yao, Wei-Cheng; Yu, Teng-Shun; Lin, Heng-Jun; Tsai, Fuu-Jen; Ho, Shinn-Ying; Kuo, Chien-Feng; Tsai, Shin-Yi BACKGROUND Chronic Fatigue Syndrome (CFS) is a...

Protective role of anti-SARS-CoV-2 antibody responses against vital organ related long COVID symptoms Yukari Magawa, Jhosiene; Jacintho, Lucas Cauê; Alves Ferreira, Marcelo; Ramos Oliveira, Jamille; Rahal Guaragna Machado, Rafael; Kuramoto Takara, Andreia; Moreno Lima de Oliveira, Renata...

Increased Risk of Post-Acute Sequalae of COVID-19 in Patients With Immune-Mediated Inflammatory Diseases Evangelin Shaloom Vitus; Christian Nikolai Sørensen; Anastasia Karachalia Sandri; Rahma Elmahdi; Tine Jess BACKGROUND AND AIMS Dysregulation of the immune system and chronic inflammation...

Hanalise Huff, Henry Roberts, Elizabeth Bartrum, Gina Norato, Nicholas Grayson, Katherine Fleig, Miciah Wilkerson, Barbara Stussman, Avindra Nath, Brian Walitt* Background: Long-COVID refers to ongoing, relapsing, or new symptoms present 30 or more days after Severe Acute Respiratory...