rapamycin

  1. forestglip

    Trial Report Low Dose Rapamycin Alleviates Clinical Symptoms of Fatigue and PEM in ME/CFS Patients via Improvement of Autophagy, 2025, Ruan et al

    Low Dose Rapamycin Alleviates Clinical Symptoms of Fatigue and PEM in ME/CFS Patients via Improvement of Autophagy Brian T. Ruan, Sarojini Bulbule, Amy Reyes, Bela Chheda, Lucinda Bateman, Jennifer Bell, Braydon Yellman, Stephanie Grach, Jon Berner, Daniel L. Peterson, David Kaufman, Avik Roy...
    • forestglip
    • Thread
    • atg13 autophagy beclin-1 me/cfs mtor pser258-atg13 rapamycin
    • Replies: 18
    • Forum: ME/CFS research
  2. forestglip

    Evaluation of off-label rapamycin use to promote healthspan in 333 adults, 2023, Kaeberlein et al

    Evaluation of off-label rapamycin use to promote healthspan in 333 adults Tammi L Kaeberlein, Alan S Green, George Haddad, Johnny Hudson, Anar Isman, Andy Nyquist, Bradley S Rosen, Yousin Suh, Sajad Zalzala, Xingyu Zhang, Mikhail V Blagosklonny, Jonathan Y An, Matt Kaeberlein Abstract...
  3. forestglip

    mTOR inhibition improves immune function in the elderly, 2014, Mannick et al

    mTOR inhibition improves immune function in the elderly Joan B. Mannick, Giuseppe Del Giudice, Maria Lattanzi, Nicholas M. Valiante, Jens Praestgaard, Baisong Huang, Michael A. Lonetto, Holden T. Maecker, John Kovarik, Simon Carson, David J. Glass, Lloyd B. Klickstein Abstract Inhibition of...
  4. B

    Rapamycin Pilot Treatment Trial for ME/CFS

    https://www.simmaronresearch.com/rapamycin-trial The First Biomarker-Driven Treatment Trial for ME/CFS Subsets Mean Success Until now, the heterogeneity of the patient population and the lack of a reliable biomarker to diagnose and prognose ME/CFS has thwarted clinical trials for both...
  5. belbyr

    mTOR activation, ATG13 inactivation and suppression of autophagy

    Split from USA: NIH National Institutes of Health news Avik Roy and Gunnar Gottschalk presented their hypothesis on a NIH ME/CFS working Group call A relevant paper is Elevated ATG13 in serum of pwME stimulates oxidative stress response in microglial cells , 2022, Gottschalk et al...
  6. Andy

    Rapamycin attenuates liver injury caused by vinyl chloride metabolite chloroethanol and lipopolysaccharide in mice, 2019, Lang et al

    Paywall, https://www.sciencedirect.com/science/article/pii/S0041008X19303539 Sci hub, not currently available on.
  7. S

    Rapamune / Rapamycin/ mTOR

    Discovered on Easter Island, rapamycin has a unique history and impacts the mTOR pathways in our bodies. mTOR is like a general contractor in sensing nutrients and regulating homeostasis in all cells. The chat touches on ME-related things like how mTOR senses ATP, keto diets, methionine...
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