precisionlife

Combinatorial Analysis of Phenotypic and Clinical Risk Factors Associated With Hospitalized COVID-19 Patients Abstract Characterization of the risk factors associated with variability in the clinical outcomes of COVID-19 is important. Our previous study using genomic data identified a...

Analysis of Genetic Host Response Risk Factors in Severe COVID-19 Patients Abstract BACKGROUND Epidemiological studies indicate that as many as 20% of individuals who test positive for COVID-19 develop severe symptoms that can require hospitalization. These symptoms include low platelet...

Systematic indication extension for drugs using patient stratification insights generated by combinatorial analytics Abstract Indication extension or repositioning of drugs can, if done well, provide a faster, cheaper, and derisked route to the approval of new therapies, creating new options...

Identification and Validation of Novel Combinatorial Genetic Risk Factors for Endometriosis across Multiple UK and US Patient Cohorts JM Sardell, S Das, GL Møller, M Sanna, K Chocian, K Taylor, AR Malinowski, C Stubberfield, A Rochlin, S Gardner Background Endometriosis affects about 10% of...

Actively Protective Combinatorial Analysis: a Scalable Novel Method for Detecting Variants that Contribute to Reduced Disease Prevalence in High-Risk Individuals Jason Sardell; Sayoni Das; Krystyna Taylor; Colin Stubberfield; Andy Malinowski; Mark Strivens; Steve Gardner We present a novel...

published paper posted on this thread here Preprint Abstract Background: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating chronic disease that lacks known pathogenesis, distinctive diagnostic criteria, and effective treatment options. Understanding the genetic...