prdx2

Dysregulated oxidative stress and lactate levels in treatment-resistant schizophrenia Fang; Zhang; Xu; Wang; He; Liao; Yuan; Tang Schizophrenia is a severe and clinically heterogeneous mental disorder, with approximately 30 % of patients developing treatment resistance to standard...

Abstract The immunoregulatory metabolite itaconate accumulates in innate immune cells upon Toll-like receptor stimulation. In response to macrophage activation by lipopolysaccharide, itaconate inhibits inflammasome activation and boosts type I interferon signalling; however, the molecular...