Type I interferons and endoplasmic reticulum stress in health and disease
Sprooten; Garg
Type I interferons (IFNs) comprise of pro-inflammatory cytokines created, as well as sensed, by all nucleated cells with the main objective of blocking pathogens-driven infections. Owing to this broad range...
SARS-CoV-2 Mitochondrial Metabolic and Epigenomic Reprogramming in COVID-19
Guarnieri; Haltom; Albrecht; Lie; Olali; Widjaja; Ranshing; Angelin; Murdock; Wallace
To determine the effects of SARS-CoV-2 infection on cellular metabolism, we conducted an exhaustive survey of the cellular metabolic...
BRD4-mediated epigenetic regulation of endoplasmic reticulum-mitochondria contact sites is governed by the mitochondrial complex III
Brandon Chen; Theophilus M Lynn-Nguyen; Pankaj Jadhav; Benjamin S Halligan; Nicholas J Rossiter; Rachel M Guerra; Sergei Koshkin; Imhoi Koo; Pietro Morlacchi...
Expression of SARS-CoV-2 Nonstructural Proteins 3 and 4 Can Tune the Unfolded Protein Response in Cell Culture
Jonathan P. Davies; Athira Sivadas; Katherine R. Keller; Brynn K. Roman; Richard J.H. Wojcikiewicz; Lars Plate
Coronaviruses (CoV), including SARS-CoV-2, modulate host proteostasis...
Unveiling the Intercompartmental Signaling Axis: Mitochondrial to ER Stress Response MERSR and its Impact on Proteostasis
Jeson J Li; Nan Xin; Chunxia Yang; Larrisa A Tavizon; Ruth Hong; Travis I Moore; Rebecca G Tharyan; Adam Antebi; Hyun-Eui Kim
Maintaining protein homeostasis is essential...
bip
endoplasmic reticulum
er stress
exercise intolerance
grp78
mitochondrial function
mouse model
muscle biopsy
p53
perk
salubrinal
seahorse
study idea
wasf3
wave3
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