pasc

Using machine learning involving diagnoses and medications as a risk prediction tool for post-acute sequelae of COVID-19 (PASC) in primary care Seika Lee, Marta A. Kisiel, Pia Lindberg, Åsa M. Wheelock, Anna Olofsson, Julia Eriksson, Judith Bruchfeld, Michael Runold, Lars Wahlström, Andrei...

Abstract: Background Shared symptoms and biological abnormalities between post-acute sequelae of SARS-CoV-2 infection (PASC) and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) could suggest common pathophysiological bases and would support coordinated treatment efforts. Empirical...

Karolinska in Sweden is currently running an EECP clinical trial for long covid. Mekanisk perifer kompression (EECP)-behandling till patienter med postcovid symtom. https://www.karolinska.se/forskning-och-utbildning/kliniska-provningar/pagaende-kliniska-studier/eecplngtidscovid/

Background Predicting which children and young people (CYP) are at the highest risk of developing post-COVID-19 condition (PCC) could improve care pathways. We aim to develop and validate prediction models for persistent PCC up to 24 months post-infection in CYP. Methods CYP who were...

Anurag Adhikari, Janesha Maddumage, Emily M Eriksson, Sarah J Annesley, Victoria A Lawson, Vanessa L Bryant and Stephanie Gras Med J Aust 2024; 221 (9): S40-S48. || doi: 10.5694/mja2.52456 Published online: 4 November 2024...

Summary Long COVID, a type of post-acute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (PASC) defined by medically unexplained symptoms following infection with SARS-CoV-2, is a newly recognized infection-associated chronic condition that causes disability in some...

Abstract While the acute manifestations of infectious diseases are well known, in some individuals, symptoms can either persist or appear after the acute period. Post-viral fatigue syndromes are recognized with other viral infections and are described after COVID-19. We have a growing number of...

Highlights: • Sleep complaints in PASC are frequent, varying from insomnia to excessive daytime sleepiness. • Five categories of sleep disorders syndromes were identified in PASC: obstructive sleep apnea, insomnia, primary hypersomnia, REM behavior disorder (RBD), and new onset circadian phase...

https://pubmed.ncbi.nlm.nih.gov/38808863/ Abstract Background: Over 30% of patients with COVID-19 have persistent symptoms that last beyond 30 days and referred to as Long COVID. Long COVID has been associated with a persistent elevation in peripheral cytokines including interleukin-6...

Highlights • Improvement from post-COVID-19 cognitive impairment (CI) is slow • Post-COVID-19 CI is molecularly distinct from Alzheimer’s disease • Post-COVID-19 CI is associated with CSF monocyte recruitment and gene alterations • Improvement from post-COVID-19 CI is linked to greater CSF...

Abstract Purpose To examine retinal and corneal neurodegenerative and retinal microvascular changes in patients after mild or asymptomatic COVID-19 disease compared to age-matched controls. Methods Thirty-five (35) patients after PCR-proven SARS-CoV-2 infection and 28 age-matched controls were...

Researching COVID to enhance recovery (RECOVER) pediatric study protocol: Rationale, objectives and design Importance: The prevalence, pathophysiology, and long-term outcomes of COVID-19 (post-acute sequelae of SARS-CoV-2 [PASC] or “Long COVID”) in children and young adults remain unknown...

Journal of Biomedical Informatics PASCLex: A comprehensive post-acute sequelae of COVID-19 (PASC) symptom lexicon derived from electronic health record clinical notes Liqin Wang, Dinah Foer, Erin MacPhaul, Ying-Chih Lo, David W. Bates, Li Zhou Abstract Objective To develop a comprehensive...

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome is common in post-acute sequelae of SARS-CoV-2 infection (PASC): Results from a post-COVID-19 multidisciplinary clinic Bonilla H, Quach TC, Tiwari A, Bonilla AE, Miglis M, Yang PC, Eggert LE, Sharifi H, Horomanski A, Subramanian A, Smirnoff L...

Summary Background Few studies have reported the long-term health effects of COVID-19. The regional population-based Linköping COVID-19 study (LinCoS) included all patients hospitalised due to COVID-19 during the first pandemic wave. Four months post-discharge, over 40% (185/433) experienced...

Abstract: SARS-CoV-2 causes profound changes in the sense of smell, including total smell loss. Although these alterations are often transient, many patients with COVID-19 exhibit olfactory dysfunction that lasts months to years. Although animal and human autopsy studies have suggested...

Association between SARS-CoV-2 Infection and Select Symptoms and Conditions 31 to 150 Days After Testing among Children and Adults Yongkang Zhang, Alfonso Romieu-Hernandez, Tegan K Boehmer, Eduardo Azziz-Baumgartner, Thomas Carton, Adi V. Gundlapalli, Julia Fearrington, Kshema Nagavedu...

Abstract: Long Covid -- the disease encompassing the post-acute sequelae of SARS-CoV-2 (PASC) -- affects millions of people around the world. Prevention of PASC is an urgent public health priority. In this work, we aimed to examine whether treatment with nirmatrelvir in the acute phase of...

Abstract Background Autoimmunity has been reported in patients with severe COVID-19. We investigated whether antinuclear/extractable-nuclear antibodies (ANAs) were present up to a year after infection, and if they were associated with the development of clinically relevant Post-Acute Sequalae...

Persistent Presence of Spike protein and Viral RNA in the Circulation of Individuals with Post-Acute Sequelae of COVID-19 Vaughn Craddock, Aatish Mahajan, Balaji Krishnamachary, Leslie Spikes, PrabhakarChalise, Navneet Kaur Dhillon SARS-CoV-2, the causative agent of COVID-19 disease has...