Mitochondrial innate immune signaling in skeletal muscle adaptation to exercise
Jin Ma; Annie Yujin Son; Youlim Son; Ping-yuan Wang; Paul M. Hwang
Exercise-induced inflammation is regarded as a response to muscle damage from mechanical stress, but controlled immune signaling can be beneficial...
https://www.medrxiv.org/content/10.1101/2025.04.13.25325733v1
Abstract
Background: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a debilitating condition with unclear etiology and no FDA-approved treatment. Recent studies suggest a possible genetic contribution to its...
Integrative Multi-Omics Framework for Causal Gene Discovery in Long COVID
Thuc Duy Le, Sindy Licette Pinero, Xiaomei Li, Lin Liu, Jiuyong Li, Sang Hong Lee, Marnie Winter, Thin Nguyen, Junpeng Zhang
Background
Long COVID, or Post–Acute Sequelae of COVID–19 (PASC), involves persistent...
Highlights
Mononuclear cells are primary drivers of the exercise response in skeletal muscle
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Release of histamine from skeletal muscle during exercise from mast cells
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Histamine receptor antagonists impair post-exercise muscle glycogen resynthesis
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Exercise-induced transcriptional...
Can inflammatory plasma proteins predict Long COVID or Fatigue severity after SARS-CoV-2 infection?
Schmitz; Freuer; Goßlau; Warm; Hyhlik-Dürr; Linseisen; Meisinger; Kirchberger
OBJECTIVES
To investigate whether specific immune response plasma proteins can predict an elevated risk of developing...
Abstract
Some survivors of humidifier disinfectants (HDs) complain of chronic, inexplicable fatigue, and post-exertional malaise (PEM). Two-day cardiopulmonary exercise tests (CPETs) performed 24 hours apart (2-day CPET protocol) are increasingly employed to evaluate PEM and related...
bip
endoplasmic reticulum
er stress
exercise intolerance
grp78
mitochondrial function
mouse model
muscle biopsy
p53
perk
salubrinal
seahorse
study idea
wasf3
wave3
Abstract
Herpesviruses have mastered host cell modulation and immune evasion to augment productive infection, life-long latency and reactivation1,2. A long appreciated, yet undefined relationship exists between the lytic–latent switch and viral non-coding RNAs3,4.
Here we identify viral...
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