orexin

  1. leokitten

    Orexin effect on physiological pulsations of the human brain, 2025, Jarvela et al

    Significance This study establishes how narcolepsy type 1 (NT1) affects brain fluid dynamics through lack of orexins by comparing NT1 patients to healthy wake and sleeping controls. Using fast functional MRI, we revealed that even during wakefulness, NT1 leads to high vasomotor and low brain...
  2. forestglip

    Review An integrative review on the orexin system and hypothalamic dysfunction in [ME/CFS]: implications for precision medicine, 2025, López-Amador

    An integrative review on the orexin system and hypothalamic dysfunction in myalgic encephalomyelitis/chronic fatigue syndrome: implications for precision medicine Noé López-Amador [Line breaks added] Abstract Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating...
  3. forestglip

    The Orexin System and Its Impact on the Autonomic Nervous and Cardiometabolic System in Post-Acute Sequelae of COVID-19, 2025, Ruhrländer et al

    The Orexin System and Its Impact on the Autonomic Nervous and Cardiometabolic System in Post-Acute Sequelae of COVID-19 Jana Ruhrländer, Styliani Syntila, Elisabeth Schieffer, Bernhard Schieffe [Line break added] Abstract Orexins (OXs) are critical for regulating circadian rhythms, arousal...
  4. Saz94

    Daridorexant - treatment for insomnia

    One of my doctors informed me today that this drug has been recently approved by NICE and is going to try me on it for my sleep issues. He said it will help when I feel too wired to get to sleep. Other insomnia sufferers might want to consider speaking to their doctor about it.
  5. Wyva

    NLS Pharmaceutics Announces the Appointment of Eric Konofal, M.D., Ph.D. as Chief Scientific Officer (ME/CFS is mentioned)

    This is a press release from a small Swiss pharmaceutical company. I'm sharing it because the newly appointed chief scientific officer said: "Our lead product candidate, Quilience®, is an exciting technology that we discovered has partial orexin-2 binding activity, and therefore, offers...
    • Wyva
    • Thread
    • leptin orexin pharmaceutical industry switzerland treatment
    • Replies: 12
    • Forum: ME/CFS research news
  6. Andy

    MS: Melatonin, Orexin, and Ceramide Interact with Platelet Activation Coagulation Factors and Gut-Microbiome-Derived Butyrate.., 2019, Anderson et al

    Full title: Multiple Sclerosis: Melatonin, Orexin, and Ceramide Interact with Platelet Activation Coagulation Factors and Gut-Microbiome-Derived Butyrate in the Circadian Dysregulation of Mitochondria in Glia and Immune Cells Open access, https://www.mdpi.com/1422-0067/20/21/5500/htm
  7. Andy

    Interleukin-1-related activity and hypocretin-1 in cerebrospinal fluid contribute to fatigue in primary Sjögren’s syndrome, 2019, Omdal et al

    Open access at https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-019-1502-8
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