nsaids

Hi all, I saw some discussion of NSAIDs already here: https://www.s4me.info/threads/nsaids.6504/ I wanted to make another thread specifically to talk about the timing of when NSAIDs are taken, and if that has an effect on helping with symptoms. Added: I'm only discussing NSAIDs for my...

Valacyclovir Plus Celecoxib for Post-Acute Sequelae of SARS-CoV-2 (PASC) A new RCT has been uploaded to clinicaltrials.gov. The study is sponsored and led by the Bateman Horne Center under the leadership of Lucinda Bateman. Brief Summary: To explore the safety and efficacy of daily doses of...

Highlights A subset of nonsteroidal anti-inflammatory drugs (NSAIDs) activates NRF2 C151 of the chaperone protein KEAP1 is necessary for NRF2 activation by indomethacin Indomethacin reduces inflammation in endotoxemia and gout models dependent on NRF2 Summary Nonsteroidal...

https://www.science.org/doi/10.1126/scitranslmed.abj9954 Beneficial inflammation Chronic pain can develop from an acute pain state. The mechanisms mediating the transition from acute to chronic pain remain to be elucidated. Here, Parisien et al. focused on the immune system using samples from...

A few years ago, on the basis of my symptom tracking, I convinced my GP that ibuprofen was making a difference and she agreed to prescribe Mobic (meloxicam) as a trial (or perhaps she humoured me). It didn't work. My understanding is that Mobic is a COX-2 inhibitor whereas ibuprofen is both a...