neurons

Abstract Rickettsial infections of the central nervous system (CNS) are manifested by severe neurological symptoms and represent a serious life-threatening condition. Despite the considerable health danger, only a few studies have been conducted focusing on the pathogenesis induced by Rickettsia...

Regulation of synaptic mitochondria by extracellular vesicles and its implications for neuronal metabolism and synaptic plasticity Yuzhou Zeng; Anna Antoniou Mitochondrial metabolism in neurons is necessary for energetically costly processes like synaptic transmission and plasticity. As...

Direct effects of prolonged TNF-α and IL-6 exposure on neural activity in human iPSC-derived neuron-astrocyte co-cultures Noah Goshi, Doris Lam, Chandrakumar Bogguri, Vivek Kurien George, Aimy Sebastian, Jose Cadena, Nicole F. Leon, Nicholas R. Hum, Dina R. Weilhammer, Nicholas O. Fischer...

iPSC-derived human cortical organoids display profound alterations of cellular homeostasis following SARS-CoV-2 infection and Spike protein exposure Gioia Cappelletti; Lorenzo Brambilla; Sergio Strizzi; Fiona Limanaqi; Valentina Melzi; Mafalda Rizzuti; Monica Nizzardo; Irma Saulle; Daria...

Membrane mechanics dictate axonal pearls-on-a-string morphology and function Griswold, Jacqueline M.; Bonilla-Quintana, Mayte; Pepper, Renee; Lee, Christopher T.; Raychaudhuri, Sumana; Ma, Siyi; Gan, Quan; Syed, Sarah; Zhu, Cuncheng; Bell, Miriam; Suga, Mitsuo; Yamaguchi, Yuuki; Chéreau, Ronan...

Maternal COVID-19 infection associated with offspring neurodevelopmental disorders Duan, Lian; Yin, Huamin; Liu, Jiaxin; Wang, Wenhang; Huang, Peijun; Liu, Li; Shen, Jingling; Wang, Zhendong Maternal COVID-19 infection increases the incidence of neurodevelopmental disorders (NDDs) in offspring...

Hello I have been working on an ME Hypothesis for the last few years. It describes three types of noradrenergic neuron dysfunction, two of which are mediated by insulin. Of course, there could be more subtypes not suggested in this hypothesis. I have made a video explaining the hypothesis-...

Microglia rescue neurons from aggregate-induced neuronal dysfunction and death through tunneling nanotubes Hannah Scheiblich; Frederik Eikens; Lena Wischhof; Sabine Opitz; Kay Jüngling; Csaba Cserép; Susanne V. Schmidt; Jessica Lambertz; Tracy Bellande; Balázs Pósfai; Charlotte Geck; Jasper...

The germline coordinates mitokine signaling Koning Shen; Jenni Durieux; Cesar G. Mena; Brant M. Webster; C. Kimberly Tsui; Hanlin Zhang; Larry Joe; Kristen M. Berendzen; Andrew Dillin The ability of mitochondria to coordinate stress responses across tissues is critical for health. In C...

SARS-CoV-2 infection causes dopaminergic neuron senescence Liuliu Yang; Tae Wan Kim; Yuling Han; Manoj S. Nair; Oliver Harschnitz; Jiajun Zhu; Pengfei Wang; So Yeon Koo; Lauretta A. Lacko; Vasuretha Chandar; Yaron Bram; Tuo Zhang; Wei Zhang; Feng He; Chendong Pan; Junjie Wu; Yaoxing Huang; Todd...

Long-COVID cognitive impairments and reproductive hormone deficits in men may stem from GnRH neuronal death Background We have recently demonstrated a causal link between loss of gonadotropin-releasing hormone (GnRH), the master molecule regulating reproduction, and cognitive deficits during...

Extensive Brain Pathologic Alterations Detected with 7.0-T MR Spectroscopic Imaging Associated with Disability in Multiple Sclerosis Eva Heckova; Assunta Dal-Bianco; Bernhard Strasser; Gilbert J. Hangel; Alexandra Lipka; Stanislav Motyka; Lukas Hingerl; Paulus S. Rommer; Thomas Berger; Petra...

Abstract Pathogen infection causes a stereotyped state of sickness that involves neuronally orchestrated behavioural and physiological changes1,2. On infection, immune cells release a ‘storm’ of cytokines and other mediators, many of which are detected by neurons3,4; yet, the responding neural...