negr1

Bi-ancestral depression GWAS in the Million Veteran Program and meta-analysis in >1.2 million individuals highlight new therapeutic directions Abstract Major depressive disorder is the most common neuropsychiatric disorder, affecting 11% of veterans. We report results of a large meta-analysis...

A quick look on AI. The NEGR1 (Neuronal Growth Regulator 1) gene, located on chromosome 1p31.1, encodes a GPI-anchored cell adhesion molecule critical for brain development, synaptic organization, and neuronal connectivity. Strongly associated with obesity, depression, and neurodevelopmental...

Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling The major anxiety disorders (ANX; including generalized anxiety disorder, panic disorder and phobias) are highly prevalent, often onset early and...

Genome-wide meta-analysis identifies genetic risk loci for mono- and polyneuropathies in 983 477 individuals Peripheral neuropathies are common neurological disorders affecting sensory, autonomic, and motor nerves, with an estimated prevalence exceeding 2% in the general population. Typical...

Dynamic extracellular interactions with AMPA receptors Synaptic plasticity in the central nervous system enables the encoding, storing, and integrating new information. AMPA (alpha-amino-3-hydroxyl-5-methyl-isoxazole-4-propionic acid)-type glutamate receptors (AMPARs) are ligand-gated ion...

Highlights • Plasma profiling of 7,288 proteins during post-exertional malaise in ME/CFS. • ME/CFS participants show sustained immune, metabolic, and neuromuscular dysregulation during post-exercise recovery. • Exertion disrupts T and B cell signaling, IL-17 pathways, and mitochondrial...

Sex-stratified genome-wide association meta-analysis of major depressive disorder Jodi T. Thomas, Jackson G. Thorp, Floris Huider, Poppy Z. Grimes, Rujia Wang, Pierre Youssef, Jonathan R. I. Coleman, Enda M. Byrne, Mark Adams, BIONIC consortium, The GLAD Study, Sarah E. Medland, Ian B. Hickie...

https://www.nature.com/articles/s41593-024-01573-y Article Published: 16 February 2024 Proteomic and transcriptomic profiling of brainstem, cerebellum and olfactory tissues in early- and late-phase COVID-19 Josefine Radke, Jenny Meinhardt, Tom Aschman, Robert Lorenz Chua, Vadim...