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Analysis of Transient Receptor Potential Ion Channels in ME/CFS Eaton-Fitch, Natalie; Muraki, Katsuhiko; Sasso, Etianne Martini; Magawa, Chandi; Marshall-Gradisnik, Sonya This chapter provides a comprehensive overview of methodologies currently employed to study ion channels, particularly...

Quick extraction of text from image NATIONAL CENTRE FOR NEUROIMMUNOLOGY AND EMERGING DISEASES LOW DOSE NALTREXONE FOR THE TREATMENT OF POST COVID-19 CONDITION Project Overview Long COVID describes the presence of various COVID-19 symptoms three months after infection lasting for at least two...

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Immune exhaustion in ME/CFS and long COVID Natalie Eaton-Fitch; Penny Rudd; Teagan Er; Livia Hool; Lara Herrero; Sonya Marshall-Gradisnik Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and long COVID are debilitating multisystemic conditions sharing similarities in immune...

Abstract Gulf War Illness (GWI) is a chronic condition characterized by multisystem symptoms that still affect up to one-third of veterans who engaged in combat in the Gulf War three decades ago. The aetiology of GWI is mainly explained by exposure to multiple toxic agents, vaccines, and...

Abstract Background Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a severe multisystemic condition associated with post-infectious onset, impaired natural killer (NK) cell cytotoxicity and impaired ion channel function, namely Transient Receptor Potential Melastatin 3 (TRPM3)...

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Abstract Background Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a serious disorder of unknown aetiology. While the pathomechanism of ME/CFS remains elusive, reduced natural killer (NK) cell cytotoxic function is a consistent immunological feature. NK cell effector functions...

NCNED 2021 Conference Thread

Abstract The transient receptor potential (TRP) superfamily of ion channels is involved in the molecular mechanisms that mediate neuroimmune interactions and activities. Recent advancements in neuroimmunology have identified a role for TRP cation channels in several neuroimmune disorders...

Abstract (1) Background: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a complex, multifaceted illness. The pathomechanism, severity and progression of this illness is still being investigated. Stressors have been implicated in symptom exacerbation for ME/CFS, however, there is...

Full title: Potential therapeutic benefit of Low Dose Naltrexone in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Role of Transient Receptor Potential Melastatin 3 ion channels in pathophysiology and treatment Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a debilitating...

Abstract (1) Background—Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a multifaceted illness characterized by profound and persistent fatigue unrelieved by rest along with a range of other debilitating symptoms. Experiences of unrefreshing and disturbed sleep are frequently...

The successful applicants for Australia’s $3m ME/CFS Targeted Call for Research (TCR) have been announced. The successful projects: Professor Sonya Marshall-Gradisnik Griffith University Grant: $1.46m Project title: Ion channel dysfunction in the pathophysiology of Myalgic Encephalomyelitis/...

A systematic review of neurological impairments in myalgic encephalomyelitis/ chronic fatigue syndrome using neuroimaging techniques Rebekah Maksoud , Stanley du Preez, Natalie Eaton-Fitch, Kiran Thapaliya, Leighton Barnden, Hélène Cabanas, Donald Staines, Sonya Marshall-Gradisnik Published...

Abstract Background Compromised natural killer (NK) cell cytotoxic function is a well-documented and consistent feature of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Other outcomes evaluated in NK cells of ME/CFS patients, however, remain equivocal. The aim of this study was to...

"Naltrexone restores impaired transient receptor potential melastatin 3 ion channel function in natural killer cells from myalgic encephalomyelitis/chronic fatigue syndrome patients" https://www.frontiersin.org/articles/10.3389/fimmu.2019.02545/abstract (No full text yet.)

Systematic review of cytokine studies by NCNED team. Results: A total of 16,702 publications were returned using our search terms. After screening of papers according to our inclusion and exclusion criteria, 15 studies were included in the review. All the included studies were observational...