narcolepsy

HLA-DQB1*03:01 strongly affects age of onset of type 1 narcolepsy independently of DQA1 and ethnicity Type 1 narcolepsy (T1N), an autoimmune disease associated with a disruption of hypocretin/orexin neurons, has conserved genetic effects transcending cultures and ethnicities. We pooled data...

Significance This study establishes how narcolepsy type 1 (NT1) affects brain fluid dynamics through lack of orexins by comparing NT1 patients to healthy wake and sleeping controls. Using fast functional MRI, we revealed that even during wakefulness, NT1 leads to high vasomotor and low brain...

https://www.pharmacytimes.com/news/fda-approves-pitolisant-for-daytime-sleepiness-in-patients-with-narcolepsy Wonder if this could help with fatigue in mecfs?

https://neurosciencenews.com/narcolepsy-autoimmune-disease-10902/