mella

Charting the Circulating Proteome in ME/CFS: Cross System Profiling and Mechanistic insights August Hoel; Fredrik Hoel; Sissel Elisabeth Furesund Dyrstad; Henrique Chapola; Ingrid Gurvin Rekeland; Kristin Risa; Kine Alme; Kari Sorland; Karl Albert Brokstad; Hans-Peter Marti; Olav Mella; Oystein...

What is this study about? This clinical trial is focused on studying the effects of a medication called daratumumab on patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). ME/CFS is a condition characterized by extreme fatigue that doesn’t improve with rest and can worsen...

Six-year follow-up of participants in two clinical trials of rituximab or cyclophosphamide in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Ingrid G. Rekeland; Kari Sørland; Lisbeth Lykke Neteland; Alexander Fosså; Kine Alme; Kristin Risa; Olav Dahl; Karl J. Tronstad; Olav Mella; Øystein...

https://bora.uib.no/bora-xmlui/handle/11250/3127770 Source: University of Bergen Date: May 2, 2024 Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Clinical trials, medical treatment and pathomechanisms ------------------------------------------------------------ Ingrid Gurvin...

Background Gastrointestinal symptoms are common in ME/CFS, but there is a knowledge gap in the literature concerning gastrointestinal motility features and detailed symptom description. Objective In this study, we aimed to characterize gastric motility and gastric symptoms in response to a...

Activity monitoring and patient-reported outcome measures in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome patients Rekeland IG, Sørland K, Bruland O, Risa K, Alme K, Dahl O, Tronstad KJ, Mella O, Fluge Ø Introduction: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a...

Full title: No replication of previously reported association with genetic variants in the T cell receptor alpha (TRA) locus for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) Abstract Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a disease with a variety of...

Fluge et al are recruiting six moderate to severe ME patients for a pilot trial on Daratumumab. Participants need to be able to travel to Haukeland University Hospital in Bergen and been diagnosed according to the Canadian criteria from 2003. They need to be between 18 and 65 years old and...

Largest ME/CFS genetic study to date. Three different cohorts totaling more than 2500 patients. First Immunochip study in ME/CFS. Possible implication of TPPP genetic region https://www.sciencedirect.com/science/article/pii/S0889159122000782 TPPP plays a key role in myelination of nerve cells...

Abstract Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating disease usually presenting after infection. Emerging evidence supports that energy metabolism is affected in ME/CFS, but a unifying metabolic phenotype has not been firmly established. We performed global...

Full title: Fine mapping of the major histocompatibility complex (MHC) in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) suggests involvement of both HLA class I and class II loci Abstract The etiology of myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is unknown, but...

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a disease with unknown etiology, no validated specific and sensitive biomarker, and no standard approved effective treatment. ME/CFS has a profound impact on the quality of life of both patients and caregivers and entails high costs...

I've just come across a patent from Fluge and Mella which looks like it was updated/published in March 2021 entitled 'Method for the treatment of chronic fatigue syndrome using an inhibitory or cytotoxic agent against plasma cells'. The description of the patent is a long read...

Full title: Reduced endothelial function in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome - results from open-label cyclophosphamide intervention study Provisionally accepted https://www.frontiersin.org/articles/10.3389/fmed.2021.642710/abstract

published in frontiers in Medicine - Family Medicine and Primary Care Results: The overall response rate by Fatigue score was 55.0% (22 of 40 patients). Fatigue score and other outcome variables showed significant improvements compared to baseline. The SF-36 Physical Function score increased...

https://www.nature.com/articles/s41598-020-62157-x

Fokus på ME (Focus on ME) is a small Norwegian charity organising ME-conferences and fundraising for ME research by Olav Mella and Øystein Fluge at Haukeland university hospital. You can read an introduction of Fokus På ME in English here. 68 000 NOK (6 800 EUR, 7 500 USD, 5 800 GBP) has been...

Activity registration in ME/CFS Would you like to be part of developing new methods for future clinical trials? We are seeking participants for a study to test the activity device Fitbit Charge 3 for measurement of physical activity in patients with ME/CFS. The study doesn't entail any...

The Norwegian ME Association donated on May 12th funds for two research projects. One of the research projects is by Fluge, Mella and their team. They want to try and find more objective ways to measure changes in patients enrolled in clinical trials by continuous measurement of physical...

━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ SUMMARY: Could the positive results of the early Fluge & Mella 2011 blinded phase II rituximab trial and 2015 open label phase II study be due to inadvertently including some Giardia lamblia ME/CFS patients in the cohort, from the 2004 Bergen Giardia...