mast cells

Butyrate Selectively Targets Super-Enhancers and Transcriptional Networks Associated with Human Mast Cell Function Jelle Folkerts; Marjolein J. W. de Bruijn; Wilfred F. J. van IJcken; Rudi W. Hendriks; Ralph Stadhouders Mast cells are key drivers of allergic inflammation. We have previously...

PACAP activates MRGPRX2 on meningeal mast cells to drive migraine-like pain Sbei, Sami; Moncrief, Taylor; Limjunyawong, Nathachit; Zeng, Yaping; Green, Dustin P. Migraine ranks among the most prevalent disorders worldwide, leading to disability and decreased quality of life in patients...

Characterisation of MRGPRX2+ mast cells in irritable bowel syndrome Lisse Decraecker; María Cuende Estévez; Samuel Van Remoortel; Runze Quan; Nathalie Stakenborg; Zheng Wang; Elisabetta De Marco; Alexandre Denadai-Souza; Maria Francesca Viola; Sonia Garcia Caraballo; Stuart Brierley; Yasuhiro...

Abstract: Visceral pain disorders such as interstitial cystitis/bladder pain syndrome (IC/BPS) and irritable bowel syndrome (IBS) often manifest concurrently in the bladder and colon. Yet, the mechanistic basis of such comorbidities and the transmission of neural hypersensitivity across organ...

The neuroimmune connectome in health and disease Wheeler, Michael A.; Quintana, Francisco J. The nervous and immune systems have complementary roles in the adaptation of organisms to environmental changes. However, the mechanisms that mediate crosstalk between the nervous and immune systems...

Highlights Mononuclear cells are primary drivers of the exercise response in skeletal muscle • Release of histamine from skeletal muscle during exercise from mast cells • Histamine receptor antagonists impair post-exercise muscle glycogen resynthesis • Exercise-induced transcriptional...

Abstract The major challenge in allergy diagnosis is development of accessible and reliable diagnostics that can predict the clinical outcome following exposure to culprit allergen(s) or cross-reactive molecules and identification of safer alternatives than the current state-of-the-art methods...

Authors: Thomas Plum Thorsten B. Feyerabend Hans-Reimer Rodewald Abstract: Mast cells are regarded as effectors in immune defense against parasites and venoms and play an essential role in the pathology of allergic diseases. More recently, mast cells have been shown to receive stimuli derived...

No signs of mast cell involvement in long-COVID: A case–control study Ole Bernt Lenning; Grete Jonsson; Tore Grimstad; Emiel A. M. Janssen; Geir Sverre Braut; Frode Berven; Roald Omdal Long-COVID caused by SARS-CoV-2 infection has significant and increasing effects on human health worldwide...

Persistent Activation of Chronic Inflammatory Pathways in Long Covid Malika Aid; Katherine McMahan; Nicole Hachmann; Jessica Miller; Erica Borducchi; David Hope; Marjorie Rowe; Eleanor Schonberg; Siline Thai; Ai-ris Collier; Janet Mullington; Dan Barouch Long Covid, or Post-Acute Sequelae of...

Mast cell activation triggered by SARS-CoV-2 causes inflammation in brain microvascular endothelial cells and microglia Wu, Meng-Li; Xie, Chengzuo; Li, Xin; Sun, Jing; Zhao, Jincun; Wang, Jian-Hua SARS-CoV-2-induced excessive inflammation in brain leads to damage of blood-brain barrier...

as a very rough tldr, for anybody wondering, of my very rough and probably wrong understanding of it, it works via a rituximab-like mechanism, except against ige. it also affects basophils and mast cells. it is used for allergy-like / histamine-like conditions. even nasal polyps. side-effects...

Coronary “Microvascular Dysfunction”: Evolving Understanding of Pathophysiology, Clinical Implications, and Potential Therapeutics Kei, Chun Yeung; Singh, Kuljit; Dautov, Rustem F.; Nguyen, Thanh H.; Chirkov, Yuliy Y.; Horowitz, John D. Until recently, it has been generally held that stable...

https://pubmed.ncbi.nlm.nih.gov/24060274/ Abstract Background: It remains elusive how allergic symptoms exhibit prominent 24-hour variations. In mammals the circadian clocks present in nearly all cells, including mast cells, drive the daily rhythms of physiology. Recently, we have shown that...

Background: The systemic inflammatory response post-SARS-CoV-2 infection increases pro-inflammatory cytokine production, multi-organ damage, and mortality rates. Mast cells (MC) modulate thrombo-inflammatory disease progression (e.g., deep vein thrombosis) and the inflammatory response...

A role for bacterial histamine in abdominal pain Gut bacteria have been implicated in the genesis of chronic pain disorders; however, the underlying mechanisms remain unclear. In new work, De Palma and colleagues show that histamine, a known neuroimmune modulator, is produced by gut bacteria and...

Could SARS-CoV-2 Spike Protein Be Responsible for Long-COVID Syndrome? Theoharis C. Theoharides Laboratory of Molecular Immunopharmacology and Drug Discovery, Department of Immunology, Tufts University School of Medicine Abstract SARS-CoV-2 infects cells via its spike protein binding to its...

Abstract Background Recently there has been increased interest in a possible association between mast cell activation (MCA) disorder and postural orthostatic tachycardia syndrome (POTS). This study examined the frequency with which symptoms and laboratory findings suggesting MCA disorder...

Paywall, https://link.springer.com/article/10.1007/s00421-021-04645-0

Local immune response to food antigens drives meal-induced abdominal pain https://www.nature.com/articles/s41586-020-03118-2