Cell membranes sustain phospholipid imbalance via cholesterol asymmetry
Milka Doktorova; Jessica L. Symons; Xiaoxuan Zhang; Hong-Yin Wang; Jan Schlegel; Joseph H. Lorent; Frederick A. Heberle; Erdinc Sezgin; Edward Lyman; Kandice R. Levental; Ilya Levental
Membranes are molecular interfaces...
Abstract:
We proposed that cerebrospinal fluid would provide objective evidence for disrupted brain metabolism in myalgic encephalomyelitis/chronic fatigue syndroome (ME/CFS). The concept of postexertional malaise (PEM) with disabling symptom exacerbation after limited exertion that does not...
Exertional Exhaustion Post-Exertional Malaise, PEM Evaluated by the Effects of Exercise on Cerebrospinal Fluid Metabolomics–Lipidomics and Serine Pathway in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
Baraniuk, James N.
Post-exertional malaise (PEM) is a defining condition of myalgic...
Reinforcing the Evidence of Mitochondrial Dysfunction in Long COVID Patients Using a Multiplatform Mass Spectrometry-Based Metabolomics Approach
Sara Martínez; Oihane E. Albóniga; María Rosa López-Huertas; Ana Gradillas; Coral Barbas
Despite the recent and increasing knowledge surrounding...
Lipidomics signature in post-COVID patient sera and its influence on the prolonged inflammatory response
Abstract
Background: The ongoing issues with post-COVID conditions (PCC), where symptoms persist long after the initial infection, highlight the need for research into blood lipid changes...
A global lipid map reveals host dependency factors conserved across SARS-CoV-2 variants
Farley, Scotland E.; Kyle, Jennifer E.; Leier, Hans C.; Bramer, Lisa M.; Weinstein, Jules B.; Bates, Timothy A.; Lee, Joon-Yong; Metz, Thomas O.; Schultz, Carsten; Tafesse, Fikadu G.
A comprehensive...
Abstract
The biology driving individual patient responses to severe acute respiratory syndrome coronavirus 2 infection remains ill understood. Here, we developed a patient-centric framework leveraging detailed longitudinal phenotyping data and covering a year after disease onset, from 215...
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