lipid rafts

A simple platelet biomarker is associated with symptom severity in major depressive disorder Aksu Gunay, Steven D. Targum, Alex D. Leow, Olusola Ajilore & Mark M. Rasenick [Line breaks added] Abstract Previous studies have shown that the heterotrimeric G protein, Gsalpha (Gsα), is ensconced...

Anti-Nociceptive Effects of Sphingomyelinase and Methyl-Beta-Cyclodextrin in the Icilin-Induced Mouse Pain Model Horváth, Ádám; Steib, Anita; Nehr-Majoros, Andrea; Kántás, Boglárka; Király, Ágnes; Racskó, Márk; Tóth, Balázs István; Szánti-Pintér, Eszter; Kudová, Eva; Skoda-Földes, Rita; Helyes...

The role of Sphingolipids in myelination and myelin stability and their involvement in childhood and adult demyelinating disorders Paola Giussani; Alessandro Prinetti; Cristina Tringali Multiple sclerosis (MS) represents the most common demyelinating disease affecting the central nervous system...

Sphingolipids and their metabolism in physiology and disease Hannun, Yusuf A.; Obeid, Lina M. Studies of bioactive lipids in general and sphingolipids in particular have intensified over the past several years, revealing an unprecedented and unanticipated complexity of the lipidome and its many...

Alterations to Sphingomyelin Metabolism Affect Hemostasis and Thrombosis Jue Wang; Shiva Keshava; Kaushik Das; Richard Kolesnick; Xian-Cheng Jiang; Usha R. Pendurthi; L. Vijaya Mohan Rao BACKGROUND: Our recent studies suggest that sphingomyelin levels in the plasma membrane influence TF (tissue...

Impact of sphingolipids on protein membrane trafficking Aguilera-Romero; Lucena; Sabido-Bozo; Muñiz Membrane trafficking is essential to maintain the spatiotemporal control of protein and lipid distribution within membrane systems of eukaryotic cells. To achieve their functional destination...

Extracellular vesicles promote autophagy in human microglia through lipid raft-dependent mechanisms Diana Romenskaja; Ugne Jonavice; Augustas Pivoriunas Autophagy dysfunction has been closely related with pathogenesis of many neurodegenerative diseases and therefore represents a potential...

Highlights Pathogenesis and salugenesis are the first and second stages of the two-stage problem of disease production and health recovery. Salugenesis, the healing cycle, the integrated stress response (ISR), and the cell danger response (CDR) each describe different aspects of the same...