Cell membranes sustain phospholipid imbalance via cholesterol asymmetry
Milka Doktorova; Jessica L. Symons; Xiaoxuan Zhang; Hong-Yin Wang; Jan Schlegel; Joseph H. Lorent; Frederick A. Heberle; Erdinc Sezgin; Edward Lyman; Kandice R. Levental; Ilya Levental
Membranes are molecular interfaces...
Oxidative Stress is a shared characteristic of ME/CFS and Long COVID
Vishnu Shankar; Julie Wilhelmy; Basil Michael; Layla Cervantes; Vamsee Mallajosyula; Ronald Davis; Michael Snyder; Shady Younis; William H Robinson; Sadasivan Shankar; Paul Mischel; Hector Bonilla; Mark Davis
More than 65...
calcium
glutathione
gpx4
lipiddropletslipids
mark davis
metformin
mitochondria
oxidative stress
reactive oxygen species
ron davis
sex differences
t cells
https://onlinelibrary.wiley.com/doi/full/10.1002/adsr.202300178
A Novel Fluorogenic Probe Reveals Lipid Droplet Dynamics in ME/CFS Fibroblasts
Siyang Ding, Oana Sanislav, Daniel Missailidis, Claire Yvonne Allan, Tze Cin Owyong, Ming-Yu Wu, Sijie Chen, Paul Robert Fisher, Sarah Jane Annesley...
Summary
We have examined the muscle biopsies of 50 patients who had postviral fatigue syndrome (PFS) for from 1 to 17 years. We found mild to severe atrophy of type II fibres in 39 biopsies, with a mild to moderate excess of lipid. On ultrastructural examination, 35 of these specimens showed...
Sphingolipids and their metabolism in physiology and disease
Hannun, Yusuf A.; Obeid, Lina M.
Studies of bioactive lipids in general and sphingolipids in particular have intensified over the past several years, revealing an unprecedented and unanticipated complexity of the lipidome and its many...
Intracellular to Interorgan Mitochondrial Communication in Striated Muscle in Health and Disease
Boardman, Neoma T; Trani, Giulia; Scalabrin, Marco; Romanello, Vanina; Wüst, Rob C I
Mitochondria sense both biochemical and energetic input in addition to communicating signals regarding the...
A global lipid map reveals host dependency factors conserved across SARS-CoV-2 variants
Farley, Scotland E.; Kyle, Jennifer E.; Leier, Hans C.; Bramer, Lisa M.; Weinstein, Jules B.; Bates, Timothy A.; Lee, Joon-Yong; Metz, Thomas O.; Schultz, Carsten; Tafesse, Fikadu G.
A comprehensive...
Lipid Biosynthesis Coordinates a Mitochondrial-to-Cytosolic Stress Response
Hyun-Eui Kim; Ana Rodrigues Grant; Milos S. Simic; Rebecca A. Kohnz; Daniel K. Nomura; Jenni Durieux; Celine E. Riera; Melissa Sanchez; Erik Kapernick; Suzanne Wolff; Andrew Dillin
Summary
Defects in mitochondrial...
Abstract
Background
Peroxisomes are single membrane-bound organelles named for their role in hydrogen peroxide production and catabolism. However, their cellular functions extend well beyond reactive oxygen species (ROS) metabolism and include fatty acid oxidation of unique substrates that...
Fereshteh Jahanbani, Rajan D. Maynard, Justin Cyril Sing, Shaghayegh Jahanbani, John J. Perrino, Damek V. Spacek, Ronald W. Davis, Michael P. Snyder
Received: January 17, 2022; Accepted: July 25, 2022; Published: August 9, 2022
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Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is...
electron microscopy
immune dysfunction
lipiddropletslipid metabolism
lipids
mitochondria
mitochondrial architecture
omf
open medicine foundation
ron davis
smpd1
sphingolipids
t cells
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