itaconate

  1. jnmaciuch

    Two-stage metabolic remodelling in macrophages in response to lipopolysaccharide and interferon-γ stimulation, 2020, Seim et al.

    Two-stage metabolic remodelling in macrophages in response to lipopolysaccharide and interferon-γ stimulation Gretchen L Seim, Emily C Britt, Steven V John, Franklin J Yeo, Aaron R Johnson, Richard S Eisenstein, David J Pagliarini, Jing Fan Abstract In response to signals associated with...
  2. Mij

    Itaconate modulates immune responses via inhibition of peroxiredoxin 5, 2025, Tomas Paulenda et al

    Abstract The immunoregulatory metabolite itaconate accumulates in innate immune cells upon Toll-like receptor stimulation. In response to macrophage activation by lipopolysaccharide, itaconate inhibits inflammasome activation and boosts type I interferon signalling; however, the molecular...
  3. Mij

    Itaconate boosts type I IFN response by disrupting cytoprotection, 2025, Theresa Ramalho

    A new study reveals a surprising mechanism by which itaconate inhibits the active site of a peroxiredoxin enzyme to amplify redox signalling and the type I interferon response in macrophages. Paywalled
  4. SNT Gatchaman

    Review Defining trained immunity and its role in health and disease, 2020, Netea et al.

    Defining trained immunity and its role in health and disease Netea, Mihai G.; Domínguez-Andrés, Jorge; Barreiro, Luis B.; Chavakis, Triantafyllos; Divangahi, Maziar; Fuchs, Elaine; Joosten, Leo A. B.; van der Meer, Jos W. M.; Mhlanga, Musa M.; Mulder, Willem J. M.; Riksen, Niels P.; Schlitzer...
  5. SNT Gatchaman

    Preprint Frataxin Deficiency Drives Shift from Mitochondrial Metabolism to Glucose Catabolism, Triggering Inflammatory Phenotype in Microglia,2023,Sciarretta+

    Frataxin Deficiency Drives a Shift from Mitochondrial Metabolism to Glucose Catabolism, Triggering an Inflammatory Phenotype in Microglia Francesca Sciarretta; Fabio Zaccaria; Andrea Ninni; Veronica Ceci; Riccardo Turchi; Savina Apolloni; Valerio Chiurchiu; Marta Tiberi; Nadia D'Ambrosi; Silvia...
  6. D

    TFEB induces mitochondrial itaconate synthesis to suppress bacterial growth in macrophages, 2022, Schuster et al

    "Successful elimination of bacteria in phagocytes occurs in the phago-lysosomal system, but also depends on mitochondrial pathways. Yet, how these two organelle systems communicate is largely unknown. Here we identify the lysosomal biogenesis factor transcription factor EB (TFEB) as regulator...
  7. SNT Gatchaman

    The Emerging Application of Itaconate: Promising Molecular Targets and Therapeutic Opportunities, 2021, Lin et al

    The Emerging Application of Itaconate: Promising Molecular Targets and Therapeutic Opportunities Jiaqi Lin, Jinxuan Ren, Dave Schwinn Gao, Yi Dai, Lina Yu Metabolites have recently been found to be involved in significant biological regulation and changes. Itaconate, an important intermediate...
  8. J

    The itaconate shunt hypothesis

  9. Andy

    Review Article: A Role for the Krebs Cycle Intermediate Citrate in Metabolic Reprogramming in Innate Immunity and Inflammation, 2018, O'Neill et al

    Review article https://www.frontiersin.org/articles/10.3389/fimmu.2018.00141/full
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