Genetic dissection of stool frequency implicates vitamin B1 metabolism and other actionable pathways in the modulation of gut motility
Gut. 2026 Jan 20
PMID: 41558814
DOI: 10.1136/gutjnl-2025-337059
Cristian Díaz-Muñoz, et al.
Open Access
Abstract
Background: Genetic...
Abstract
Introduction: Gastro-esophageal reflux disease (GERD) is a chronic condition encompassing visceral pain - experienced as heartburn and, in some cases, inflammation of the esophageal mucosa. Although mast cell dysregulation has been described in disorders of gut-brain interaction, it has...
A cellular basis for heightened gut sensitivity in females
Visceral pain disorders, such as irritable bowel syndrome, exhibit a marked female prevalence. Enhanced signaling between enterochromaffin (EC) cells in the gut epithelium and mucosal sensory nerve fibers likely contributes to this sex...
A Glutamatergic Medial Prefrontal Cortex–Locus Coeruleus Circuit Drives Intestinal Dysmotility in Diarrhea-Predominant Irritable Bowel Syndrome
Diarrhea-predominant irritable bowel syndrome (IBS-D) is a common chronic disorder of gut–brain interaction characterized by intestinal dysmotility...
Comparison of Digitally Delivered Gut-Directed Hypnotherapy Program With an Active Control for Irritable Bowel Syndrome
https://pubmed.ncbi.nlm.nih.gov/38940439/
Ellen J Anderson, Simone L Peters, Peter R Gibson, Emma P Halmos
Abstract
Introduction: Gut-directed hypnotherapy (GDH) treats...
Microglial Activation in Nociplastic Pain: From Preclinical Models to PET Neuroimaging and Implications for Targeted Therapeutic Strategies
Nociplastic pain has recently been introduced as a third entity for identifying patients suffering from chronic pain that arises from altered nociception...
Identification of human gut bacteria that produce bioactive serotonin and promote colonic innervation
The gut microbiota regulates host intestinal serotonin synthesis, thereby promoting the development and maintenance of the enteric nervous system, which controls bowel motility.
Functional...
A longitudinal evaluation of gastrointestinal symptoms in children with autism spectrum disorder
https://journals.sagepub.com/doi/10.1177/13623613251362349
Gastrointestinal symptoms are frequently reported in children diagnosed with autism spectrum disorder. This study sought to determine the...
Ignored, Dismissed, and Minimized: Understanding the Harmful Consequences of Invalidation in Health Care—A Systematic Meta-Synthesis of Qualitative Research
Allyson C. Bontempo, John M. Bontempo, Paul R. Duberstein
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Abstract
The upsurge in the prevalence of contested...
Characterisation of MRGPRX2+ mast cells in irritable bowel syndrome
Lisse Decraecker; María Cuende Estévez; Samuel Van Remoortel; Runze Quan; Nathalie Stakenborg; Zheng Wang; Elisabetta De Marco; Alexandre Denadai-Souza; Maria Francesca Viola; Sonia Garcia Caraballo; Stuart Brierley; Yasuhiro...
Abstract:
Visceral pain disorders such as interstitial cystitis/bladder pain syndrome (IC/BPS) and irritable bowel syndrome (IBS) often manifest concurrently in the bladder and colon. Yet, the mechanistic basis of such comorbidities and the transmission of neural hypersensitivity across organ...
New-onset gastrointestinal disorders in COVID-19 patients 3.5 years post-infection in the inner-city population in the Bronx
Changela, Sagar; Ashraf, Samad; Lu, Justin Y. ; Duong, Kevin E. ; Henry, Sonya; Wang, Stephen H. ; Duong, Tim Q.
This study examined the incidence, characteristics, and...
Background
Chronic overlapping pain conditions (COPCs), pain-related conditions that frequently occur together, may occur in patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and could impact illness severity. This study aimed to identify comorbid COPCs in patients with...
Objective: Comorbidities between internalizing disorders (IDs) and functional disorders (FDs) are well-documented, indicating shared pathways. However, their symptom-level relationships have been largely unexplored. This exploratory study employs a network approach to investigate symptoms of...
A low FODMAP diet plus traditional dietary advice versus a low-carbohydrate diet versus pharmacological treatment in irritable bowel syndrome (CARBIS): a single-centre, single-blind, randomised controlled trial
https://www.thelancet.com/journals/langas/article/PIIS2468-1253(24)00045-1/abstract...
Evidence of shared genetic factors in the etiology of gastrointestinal disorders and endometriosis and clinical implications for disease management
Fei Yang; Yeda Wu; Richard Hockey; Jenny Doust; Gita D. Mishra; Grant W. Montgomery; Sally Mortlock
In clinical practice, the co-existence of...
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