integrated stress response

  1. Wyva

    Immunometabolic changes and potential biomarkers in CFS peripheral immune cells revealed by single-cell RNA sequencing, 2024, Sun et al

    Abstract The pathogenesis of Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) remains unclear, though increasing evidence suggests inflammatory processes play key roles. In this study, single-cell RNA sequencing (scRNA-seq) of peripheral blood mononuclear cells (PBMCs) was used to...
    • Wyva
    • Thread
    • 2024 amyloid amyloid precursor protein biomarker cd74 china cytoskeleton esrra hla hla-dqb1 immune dysregulation immunometabolism integrated stress response nk cells oestrogen pbmc resistin single-cell rna-sequencing t cells
    • Replies: 26
    • Forum: ME/CFS research
  2. SNT Gatchaman

    Specific activation of the integrated stress response uncovers regulation of central carbon metabolism and lipid droplet biogenesis, 2024, Labbé et al

    Specific activation of the integrated stress response uncovers regulation of central carbon metabolism and lipid droplet biogenesis Labbé, Katherine; LeBon, Lauren; King, Bryan; Vu, Ngoc; Stoops, Emily H.; Ly, Nina; Lefebvre, Austin E. Y. T.; Seitzer, Phillip; Krishnan, Swathi; Heo, Jin-Mi...
  3. SNT Gatchaman

    The germline coordinates mitokine signaling, 2024, Shen et al.

    The germline coordinates mitokine signaling Koning Shen; Jenni Durieux; Cesar G. Mena; Brant M. Webster; C. Kimberly Tsui; Hanlin Zhang; Larry Joe; Kristen M. Berendzen; Andrew Dillin The ability of mitochondria to coordinate stress responses across tissues is critical for health. In C...
  4. SNT Gatchaman

    Review SARS-CoV-2 Mitochondrial Metabolic and Epigenomic Reprogramming in COVID-19, 2024, Guarnieri et al.

    SARS-CoV-2 Mitochondrial Metabolic and Epigenomic Reprogramming in COVID-19 Guarnieri; Haltom; Albrecht; Lie; Olali; Widjaja; Ranshing; Angelin; Murdock; Wallace To determine the effects of SARS-CoV-2 infection on cellular metabolism, we conducted an exhaustive survey of the cellular metabolic...
    • SNT Gatchaman
    • Thread
    • atf6 cgas-sting epigenetics fgf21 gdf15 glycolysis hif-1 histone innate immune system integrated stress response interferon metabolic reprogramming metabolism mitochondria oxidative phosphorylation pentose phospate pathway perk tlr-9 upr
    • Replies: 2
    • Forum: Long Covid research
  5. SNT Gatchaman

    Review Mitochondrial quality control pathways sense mitochondrial protein import, 2023, Laurie P. Lee-Glover and Timothy E. Shutt

    Mitochondrial quality control pathways sense mitochondrial protein import Laurie P. Lee-Glover; Timothy E. Shutt Mitochondrial quality control (MQC) mechanisms are required to maintain a functional proteome, which enables mitochondria to perform a myriad of important cellular functions from...
    • SNT Gatchaman
    • Thread
    • autophagy cell signalling fgf21 integrated stress response metabolism mitochondria mitophagy steroids unfolded protein response upr
    • Replies: 1
    • Forum: Other health news and research
  6. SNT Gatchaman

    Preprint BRD4-mediated epigenetic regulation of endoplasmic reticulum-mitochondria contact sites is governed by the mitochondrial complex III, 2024, Chen et al

    BRD4-mediated epigenetic regulation of endoplasmic reticulum-mitochondria contact sites is governed by the mitochondrial complex III Brandon Chen; Theophilus M Lynn-Nguyen; Pankaj Jadhav; Benjamin S Halligan; Nicholas J Rossiter; Rachel M Guerra; Sergei Koshkin; Imhoi Koo; Pietro Morlacchi...
    • SNT Gatchaman
    • Thread
    • brd4 complex 3 endoplasmic reticulum epigenetics hif-1 hypoxia integrated stress response jak inhibitors jak-stat mitochondria mitochondrial dynamics perk
    • Replies: 0
    • Forum: Other health news and research
  7. SNT Gatchaman

    Core mitochondrial genes are down-regulated during SARS-CoV-2 infection of rodent and human hosts, 2023, Guarnieri et al.

    Core mitochondrial genes are down-regulated during SARS-CoV-2 infection of rodent and human hosts Joseph W. Guarnieri; Joseph M. Dybas; Hossein Fazelinia; Man S. Kim; Justin Frere; Yuanchao Zhang; Yentli Soto Albrecht; Deborah G. Murdock; Alessia Angelin; Larry N. Singh; Scott L. Weiss; Sonja M...
    • SNT Gatchaman
    • Thread
    • covid fgf21 gdf15 glycolysis glyolysis hif-1 integrated stress response long covid mavs metabolism micro-rna mitochondria oxphos
    • Replies: 14
    • Forum: Long Covid research
  8. SNT Gatchaman

    A coordinated multiorgan metabolic response contributes to human mitochondrial myopathy, 2023, Southwell et al.

    A coordinated multiorgan metabolic response contributes to human mitochondrial myopathy Nneka Southwell; Guido Primiano; Viraj Nadkarni; Nabeel Attarwala; Emelie Beattie; Dawson Miller; Sumaitaah Alam; Irene Liparulo; Yevgeniya I Shurubor; Maria Lucia Valentino; Valerio Carelli; Serenella...
    • SNT Gatchaman
    • Thread
    • amino acids atf4 fatty acid metabolism fatty acid oxidation fgf21 gdf15 integrated stress response lipid droplets lipid metabolism lipids metabolism mitochondria mtor muscle myopathy tca cycle
    • Replies: 4
    • Forum: Other health news and research
  9. D

    Adaptation to mitochondrial stress requires CHOP-directed tuning of ISR

    https://advances.sciencemag.org/content/7/22/eabf0971/tab-article-info https://doi.org/10.1126/sciadv.abf0971 Abstract In response to disturbed mitochondrial gene expression and protein synthesis, an adaptive transcriptional response sharing a signature of the integrated stress response (ISR)...
  10. Indigophoton

    Metabolic features and regulation of the healing cycle—A new model for chronic disease pathogenesis and treatment, Robert K Naviaux, 2018

    Not specifically about ME, but includes CFS in the list of conditions considered. https://www.sciencedirect.com/science/article/pii/S1567724918301053#tf0005
    • Indigophoton
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    • 2018 allostatic load antipurinergic therapy cell danger response chronic illness healing cycle integrated stress response m0 m1 m2 mitochondria metabokines metabolic memory mitochondria mitochondrial nexus naviaux purinergic signaling
    • Replies: 71
    • Forum: Other health news and research
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