insular cortex

Intralaminar thalamus relays basal ganglia output to the insular cortex to drive tic generation Motor and vocal tics accompanied by premonitory urges are hallmark symptoms of Tourette syndrome (TS), yet the underlying neuronal mechanisms remain incompletely understood. Here, we establish a...

https://www.cell.com/cell/pdf/S0092-8674(21)01223-X.pdf Research done in mice. Highlights Neuronal ensembles in the InsCtx are activated during peripheral inflammation Reactivation of these neurons is sufficient to retrieve peripheral inflammation These InsCtx neurons project to autonomic...